Materials approaches for modulating neural tissue responses to implanted microelectrodes through mechanical and biochemical means

Salah Sommakia, Heui C. Lee, Janak Gaire, Kevin J. Otto

Research output: Contribution to journalReview articlepeer-review

42 Scopus citations

Abstract

Implantable intracortical microelectrodes face an uphill struggle for widespread clinical use. Their potential for treating a wide range of traumatic and degenerative neural disease is hampered by their unreliability in chronic settings. A major factor in this decline in chronic performance is a reactive response of brain tissue, which aims to isolate the implanted device from the rest of the healthy tissue. In this review we present a discussion of materials approaches aimed at modulating the reactive tissue response through mechanical and biochemical means. Benefits and challenges associated with these approaches are analyzed, and the importance of multimodal solutions tested in emerging animal models are presented.

Original languageEnglish
Pages (from-to)319-328
Number of pages10
JournalCurrent Opinion in Solid State and Materials Science
Volume18
Issue number6
DOIs
StatePublished - Dec 1 2014

Keywords

  • Glia
  • Interface
  • Microdevice
  • Neurons
  • Prostheses

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