Mast cell granules within endothelial cells: a possible signal in the inflammatory process?

K. DeSchryver-Kecskemeti; J. R. Williamson; B. A. Jakschik; R. E. Clouse; D. H. Alpers

Mast cell granules within endothelial cells: a possible signal in the inflammatory process?

K. DeSchryver-Kecskemeti, J. R. Williamson, B. A. Jakschik, R. E. Clouse, D. H. Alpers

Gastroenterology

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14 Scopus citations

Abstract

Mast cell-endothelial cell interactions have long been suspected to be important in inflammation. The detail of the pathways of communication have yet to be elucidated. In this report we describe, for the first time, mast cell granules within endothelial cells of colonic capillaries in a patient with florid colitis, as well as rats with experimentally induced mast cell degranulation. We postulate that this phenomenon may occur more generally during immunologically mediated inflammatory cell degranulation, and may be one mechanism of communication to endothelium.

Original language	English
Pages (from-to)	343-347
Number of pages	5
Journal	Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Volume	5
Issue number	3
State	Published - May 1992

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title = "Mast cell granules within endothelial cells: a possible signal in the inflammatory process?",

abstract = "Mast cell-endothelial cell interactions have long been suspected to be important in inflammation. The detail of the pathways of communication have yet to be elucidated. In this report we describe, for the first time, mast cell granules within endothelial cells of colonic capillaries in a patient with florid colitis, as well as rats with experimentally induced mast cell degranulation. We postulate that this phenomenon may occur more generally during immunologically mediated inflammatory cell degranulation, and may be one mechanism of communication to endothelium.",

author = "K. DeSchryver-Kecskemeti and Williamson, {J. R.} and Jakschik, {B. A.} and Clouse, {R. E.} and Alpers, {D. H.}",

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volume = "5",

pages = "343--347",

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Mast cell granules within endothelial cells : a possible signal in the inflammatory process? / DeSchryver-Kecskemeti, K.; Williamson, J. R.; Jakschik, B. A.; Clouse, R. E.; Alpers, D. H.

In: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 5, No. 3, 05.1992, p. 343-347.

Research output: Contribution to journal › Article › peer-review

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T1 - Mast cell granules within endothelial cells

T2 - a possible signal in the inflammatory process?

AU - DeSchryver-Kecskemeti, K.

AU - Williamson, J. R.

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AU - Clouse, R. E.

AU - Alpers, D. H.

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AB - Mast cell-endothelial cell interactions have long been suspected to be important in inflammation. The detail of the pathways of communication have yet to be elucidated. In this report we describe, for the first time, mast cell granules within endothelial cells of colonic capillaries in a patient with florid colitis, as well as rats with experimentally induced mast cell degranulation. We postulate that this phenomenon may occur more generally during immunologically mediated inflammatory cell degranulation, and may be one mechanism of communication to endothelium.

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