Mass spectrometry-based shotgun lipidomics – a critical review from the technical point of view

Research output: Contribution to journalReview article

25 Scopus citations

Abstract

Over the past decade, mass spectrometry (MS)-based “shotgun lipidomics” has emerged as a powerful tool for quantitative and qualitative analysis of the complex lipids in the biological system. The aim of this critical review is to give the interested reader a concise overview of the current state of the technology, focused on lipidomic analysis by mass spectrometry. The pros and cons, and pitfalls associated with each available “shotgun lipidomics” method are discussed; and the new strategies for improving the current methods are described. A list of important papers and reviews that are sufficient rather than comprehensive, covering all the aspects of lipidomics including the workflow, methodology, and fundamentals is also compiled for readers to follow. [Figure not available: see fulltext.].

Original languageEnglish
Pages (from-to)6387-6409
Number of pages23
JournalAnalytical and Bioanalytical Chemistry
Volume410
Issue number25
DOIs
StatePublished - Oct 1 2018

Keywords

  • Collision induced dissociation
  • Electrospray ionization
  • Lipid
  • Lipidomics
  • MALDI
  • Mass spectrometry

Fingerprint Dive into the research topics of 'Mass spectrometry-based shotgun lipidomics – a critical review from the technical point of view'. Together they form a unique fingerprint.

  • Cite this