Abstract
Hematopoietic stem cells egress and traffic to the bone marrow throughout the normal human life span. This egress process is essential during inflammation and is exploited for peripheral blood stem cell mobilization. This chapter reviews the bone marrow microenvironment and its role in stem cell mobilization. It reviews critical components of the bone marrow microenvironment and data on stem cell trafficking to the niche and mobilization from the niche. It highlights studies that describe the niche and normal stem cell homeostasis and the biology of stem cell mobilization. Finally, stem cell mobilizing agents are described and their mechanism is reviewed.
| Original language | English |
|---|---|
| Title of host publication | Thomas' Hematopoietic Cell Transplantation |
| Subtitle of host publication | Fifth Edition |
| Publisher | Wiley Blackwell |
| Pages | 50-67 |
| Number of pages | 18 |
| Volume | 1-2 |
| ISBN (Electronic) | 9781118416426 |
| ISBN (Print) | 9781118416006 |
| DOIs | |
| State | Published - Jan 1 2016 |
Keywords
- CXCL12
- G-CSF
- Microenvironment
- Mobilization
- Niche
- Peripheral blood stem cells
- Plerixafor
- Stem cell factor
- VLA-4