Hematopoietic stem cells egress and traffic to the bone marrow throughout the normal human life span. This egress process is essential during inflammation and is exploited for peripheral blood stem cell mobilization. This chapter reviews the bone marrow microenvironment and its role in stem cell mobilization. It reviews critical components of the bone marrow microenvironment and data on stem cell trafficking to the niche and mobilization from the niche. It highlights studies that describe the niche and normal stem cell homeostasis and the biology of stem cell mobilization. Finally, stem cell mobilizing agents are described and their mechanism is reviewed.

Original languageEnglish
Title of host publicationThomas' Hematopoietic Cell Transplantation
Subtitle of host publicationFifth Edition
PublisherWiley Blackwell
Number of pages18
ISBN (Electronic)9781118416426
ISBN (Print)9781118416006
StatePublished - Jan 1 2016


  • CXCL12
  • G-CSF
  • Microenvironment
  • Mobilization
  • Niche
  • Peripheral blood stem cells
  • Plerixafor
  • Stem cell factor
  • VLA-4


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