TY - JOUR
T1 - Marrow fat and bone-new perspectives
AU - Fazeli, Pouneh K.
AU - Horowitz, Mark C.
AU - MacDougald, Ormond A.
AU - Scheller, Erica L.
AU - Rodeheffer, Matthew S.
AU - Rosen, Clifford J.
AU - Klibanski, Anne
PY - 2013/3
Y1 - 2013/3
N2 - Context: There is growing interest in the relationship between bone mineral density, bone strength, and fat depots. Marrow adipose tissue, a well-established component of the marrow environment, is metabolically distinct from peripheral fat depots, but its functional significance is unknown. Objective: In this review, we discuss animal and human data linking the marrow adipose tissue depot to parameters of bone density and integrity as well as the potential significance of marrow adipose tissue in metabolic diseases associated with bone loss, including type 1 diabetes mellitus and anorexia nervosa. Potential hormonal determinants of marrow adipose tissue are also discussed. Conclusions: We conclude that whereas most animal and human data demonstrate an inverse association between marrow adipose tissue and measures of bone density and strength, understanding the functional significance of marrow adipose tissue and its hormonal determinants will becritical to better understanding its role in skeletal integrity and the role of marrow adipose tissue in the pathophysiology of bone loss.
AB - Context: There is growing interest in the relationship between bone mineral density, bone strength, and fat depots. Marrow adipose tissue, a well-established component of the marrow environment, is metabolically distinct from peripheral fat depots, but its functional significance is unknown. Objective: In this review, we discuss animal and human data linking the marrow adipose tissue depot to parameters of bone density and integrity as well as the potential significance of marrow adipose tissue in metabolic diseases associated with bone loss, including type 1 diabetes mellitus and anorexia nervosa. Potential hormonal determinants of marrow adipose tissue are also discussed. Conclusions: We conclude that whereas most animal and human data demonstrate an inverse association between marrow adipose tissue and measures of bone density and strength, understanding the functional significance of marrow adipose tissue and its hormonal determinants will becritical to better understanding its role in skeletal integrity and the role of marrow adipose tissue in the pathophysiology of bone loss.
UR - http://www.scopus.com/inward/record.url?scp=84874817050&partnerID=8YFLogxK
U2 - 10.1210/jc.2012-3634
DO - 10.1210/jc.2012-3634
M3 - Review article
C2 - 23393168
AN - SCOPUS:84874817050
SN - 0021-972X
VL - 98
SP - 935
EP - 945
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
IS - 3
ER -