TY - JOUR
T1 - Markov chain Monte Carlo linkage analysis of a complex qualitative phenotype
AU - Hinrichs, Anthony
AU - Lin, Jennifer H.
AU - Reich, Theodore
AU - Bierut, Laura
AU - Suarez, Brian K.
PY - 1999
Y1 - 1999
N2 - We tested a new computer program, LOKI, that implements a reversible jump Markov chain Monte Carlo (MCMC) technique for segregation and linkage analysis. Our objective was to determine whether this software, designed for use with continuously distributed phenotypes, has any efficacy when applied to the discrete disease states of the simulated data from the Mordor data from GAW Problem 1. Although we were able to identify the genomic location for two of the three quantitative trait loci by repeated application of the software, the MCMC sampler experienced significant mixing problems indicating that the method, as currently formulated in LOKI, was not suitable for the discrete phenotypes in this data set.
AB - We tested a new computer program, LOKI, that implements a reversible jump Markov chain Monte Carlo (MCMC) technique for segregation and linkage analysis. Our objective was to determine whether this software, designed for use with continuously distributed phenotypes, has any efficacy when applied to the discrete disease states of the simulated data from the Mordor data from GAW Problem 1. Although we were able to identify the genomic location for two of the three quantitative trait loci by repeated application of the software, the MCMC sampler experienced significant mixing problems indicating that the method, as currently formulated in LOKI, was not suitable for the discrete phenotypes in this data set.
KW - Linkage
KW - Quantitative trait linkage
UR - http://www.scopus.com/inward/record.url?scp=0032758369&partnerID=8YFLogxK
U2 - 10.1002/gepi.13701707100
DO - 10.1002/gepi.13701707100
M3 - Article
C2 - 10597502
AN - SCOPUS:0032758369
SN - 0741-0395
VL - 17
SP - S615-S620
JO - Genetic Epidemiology
JF - Genetic Epidemiology
IS - SUPPL. 1
ER -