Markers of maternal and infant metabolism are associated with ventricular dysfunction in infants of obese women with type 2 diabetes

W. Todd Cade, Philip T. Levy, Rachel A. Tinius, Mehgna D. Patel, Swati Choudhry, Mark R. Holland, Gautam K. Singh, Alison G. Cahill

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

BackgroundTo test the hypothesis that infants born to obese women with pre-gestational type 2 diabetes mellitus (IBDMs) have ventricular dysfunction at 1 month that is associated with markers of maternal lipid and glucose metabolism.MethodsIn a prospective observational study of IBDMs (OB+DM, n=25), echocardiographic measures of septal, left (LV) and right ventricular (RV) function, and structure were compared at 1 month of age with those in infants born to OB mothers without DM (OB, n=24) and to infants born to non-OB mothers without DM (Lean, n=23). Basal maternal lipid and glucose kinetics and maternal plasma and infant (cord) plasma were collected for hormone and cytokine analyses.ResultsRV, LV, and septal strain measures were lower in the OB+DM infants compared with those in other groups, without evidence of septal hypertrophy. Maternal hepatic insulin sensitivity, maternal plasma free-fatty-acid concentration, and cord plasma insulin and leptin most strongly predicted decreased septal strain in OB+DM infants.ConclusionIBDMs have reduced septal function at 1 month in the absence of septal hypertrophy, which is associated with altered maternal and infant lipid and glucose metabolism. These findings suggest that maternal obesity and DM may have a prolonged impact on the cardiovascular health of their offspring, despite the resolution of cardiac hypertrophy.

Original languageEnglish
Pages (from-to)768-775
Number of pages8
JournalPediatric research
Volume82
Issue number5
DOIs
StatePublished - Nov 1 2017

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