TY - JOUR
T1 - Marked increase in Ia-bearing macrophages during Trypanosoma cruzi infection
AU - Behbehani, Kazem
AU - Pan, Steve C.
AU - Unanue, Emil R.
N1 - Funding Information:
The research and investigators were supported by grants from the National Institutes of Health, the UNDP/World Bank-WHO Special Programme for Research and Training in Tropical Diseases, and The Kuwait Institute for Scientific Research.
PY - 1981/5
Y1 - 1981/5
N2 - In this paper, we show that, during infection with Trypanosoma cruzi, there is a dramatic shift in the content of macrophage-bearing I-region-associated antigens (Ia). The percentage of Ia-bearing macrophages in normal peritoneal exudate is about 10%. This number changes to 50 to 100% after T. cruzi infection. The Ia-bearing cells are typical macrophages. Experiments were done attempting to explain the change in the Ia-bearing macrophages. Part of the influx of Ia-positive macrophages is mediated by immune T cells. Furthermore, direct conversion of Ia-negative macrophages to Ia-positive by direct infestation with T. cruzi led to negative results. We speculate that such a dramatic change in the composition of the macrophage may be an important immunoregulatory event in trypanosomiasis inasmuch as Ia-positive cells are essential for most T-cell reactions.
AB - In this paper, we show that, during infection with Trypanosoma cruzi, there is a dramatic shift in the content of macrophage-bearing I-region-associated antigens (Ia). The percentage of Ia-bearing macrophages in normal peritoneal exudate is about 10%. This number changes to 50 to 100% after T. cruzi infection. The Ia-bearing cells are typical macrophages. Experiments were done attempting to explain the change in the Ia-bearing macrophages. Part of the influx of Ia-positive macrophages is mediated by immune T cells. Furthermore, direct conversion of Ia-negative macrophages to Ia-positive by direct infestation with T. cruzi led to negative results. We speculate that such a dramatic change in the composition of the macrophage may be an important immunoregulatory event in trypanosomiasis inasmuch as Ia-positive cells are essential for most T-cell reactions.
UR - http://www.scopus.com/inward/record.url?scp=0019460993&partnerID=8YFLogxK
U2 - 10.1016/0090-1229(81)90062-3
DO - 10.1016/0090-1229(81)90062-3
M3 - Article
C2 - 6784986
AN - SCOPUS:0019460993
SN - 0090-1229
VL - 19
SP - 190
EP - 195
JO - Clinical Immunology and Immunopathology
JF - Clinical Immunology and Immunopathology
IS - 2
ER -