Mapping vascular and glomerular pathology in a rabbit model of neonatal acute kidney injury using MRI

Neda Parvin, Jennifer R. Charlton, Edwin J. Baldelomar, Jamal J. Derakhshan, Kevin M. Bennett

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Acute kidney injury (AKI) in premature neonates is common due to the administration of life-saving therapies. The impact of AKI on renal morphology and susceptibility to further renal damage is poorly understood. Recent advances in radiological imaging have allowed integration of soft tissue morphology in the intact organ, facilitating a more complete understanding of changes in tissue microstructure associated with pathology. Here, we applied magnetic resonance imaging (MRI) to detect both glomerular and vascular changes in a rabbit model of neonatal AKI, induced by indomethacin and gentamicin. Using combined spin-echo MRI and cationic ferritin enhanced gradient-echo MRI (CFE-MRI), we observed (a) an increased cortical arterial diameter in the AKI cohort compared to healthy controls, and (b) focal loss of vascular density and glomerular loss in a circumferential band ~1 mm from the cortical surface. This combined use of vascular and glomerular imaging may give insight into the etiology of AKI and its impact on renal health later in life.

Original languageEnglish
Pages (from-to)2716-2728
Number of pages13
JournalAnatomical Record
Volume303
Issue number10
DOIs
StatePublished - Oct 1 2020

Keywords

  • acute kidney injury
  • glomerulus
  • magnetic resonance imaging (MRI)
  • nephron number
  • vasculature

Fingerprint

Dive into the research topics of 'Mapping vascular and glomerular pathology in a rabbit model of neonatal acute kidney injury using MRI'. Together they form a unique fingerprint.

Cite this