Mapping the locations of estradiol and potent neuroprotective analogues in phospholipid bilayers by REDOR

Lynette Cegelski; Charles V. Rice; Robert D. O'Connor; Amy L. Caruano; Gregory P. Tochtrop; Zu Yun Cai; Douglas F. Covey; Jacob Schaefer

doi:10.1002/ddr.20048

Mapping the locations of estradiol and potent neuroprotective analogues in phospholipid bilayers by REDOR

Lynette Cegelski
, Charles V. Rice
, Robert D. O'Connor
, Amy L. Caruano
, Gregory P. Tochtrop
, Zu Yun Cai
, Douglas F. Covey
, Jacob Schaefer

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Estrogens are potent antioxidants and neuroprotectants. They have become the focus of drug development efforts aimed at treating and preventing neuronal damage in stroke-related brain damage, Alzheimer's disease, and Parkinson's disease. ¹³C{³¹P} and ¹³C{¹⁹F} rotational-echo double-resonance NMR have been used to map the locations of 17β-estradiol (estradiol), 17β-estradiol 17-benzoate (estradiol benzoate), and 17β-2-(1-adamantyl)estradiol (adamantyl estradiol) in ¹⁹F-labeled DPPC phospholipid multilamellar vesicles. Placement of the estrogen molecules in lipid bilayers is correlated with the differences in their neuroprotective potency.

Original language	English
Pages (from-to)	93-102
Number of pages	10
Journal	Drug Development Research
Volume	66
Issue number	2
DOIs	https://doi.org/10.1002/ddr.20048
State	Published - Oct 2005

Keywords

Estrogens
Lipid bilayers
Membranes
Neuroprotection
REDOR
Solid-state NMR

Access to Document

10.1002/ddr.20048

Cite this

@article{67ffbe18c423437a9c7c1b5582d8062b,

title = "Mapping the locations of estradiol and potent neuroprotective analogues in phospholipid bilayers by REDOR",

abstract = "Estrogens are potent antioxidants and neuroprotectants. They have become the focus of drug development efforts aimed at treating and preventing neuronal damage in stroke-related brain damage, Alzheimer's disease, and Parkinson's disease. 13C\{31P\} and 13C\{19F\} rotational-echo double-resonance NMR have been used to map the locations of 17β-estradiol (estradiol), 17β-estradiol 17-benzoate (estradiol benzoate), and 17β-2-(1-adamantyl)estradiol (adamantyl estradiol) in 19F-labeled DPPC phospholipid multilamellar vesicles. Placement of the estrogen molecules in lipid bilayers is correlated with the differences in their neuroprotective potency.",

keywords = "Estrogens, Lipid bilayers, Membranes, Neuroprotection, REDOR, Solid-state NMR",

author = "Lynette Cegelski and Rice, \{Charles V.\} and O'Connor, \{Robert D.\} and Caruano, \{Amy L.\} and Tochtrop, \{Gregory P.\} and Cai, \{Zu Yun\} and Covey, \{Douglas F.\} and Jacob Schaefer",

year = "2005",

month = oct,

doi = "10.1002/ddr.20048",

language = "English",

volume = "66",

pages = "93--102",

journal = "Drug Development Research",

issn = "0272-4391",

number = "2",

}

TY - JOUR

T1 - Mapping the locations of estradiol and potent neuroprotective analogues in phospholipid bilayers by REDOR

AU - Cegelski, Lynette

AU - Rice, Charles V.

AU - O'Connor, Robert D.

AU - Caruano, Amy L.

AU - Tochtrop, Gregory P.

AU - Cai, Zu Yun

AU - Covey, Douglas F.

AU - Schaefer, Jacob

PY - 2005/10

Y1 - 2005/10

N2 - Estrogens are potent antioxidants and neuroprotectants. They have become the focus of drug development efforts aimed at treating and preventing neuronal damage in stroke-related brain damage, Alzheimer's disease, and Parkinson's disease. 13C{31P} and 13C{19F} rotational-echo double-resonance NMR have been used to map the locations of 17β-estradiol (estradiol), 17β-estradiol 17-benzoate (estradiol benzoate), and 17β-2-(1-adamantyl)estradiol (adamantyl estradiol) in 19F-labeled DPPC phospholipid multilamellar vesicles. Placement of the estrogen molecules in lipid bilayers is correlated with the differences in their neuroprotective potency.

AB - Estrogens are potent antioxidants and neuroprotectants. They have become the focus of drug development efforts aimed at treating and preventing neuronal damage in stroke-related brain damage, Alzheimer's disease, and Parkinson's disease. 13C{31P} and 13C{19F} rotational-echo double-resonance NMR have been used to map the locations of 17β-estradiol (estradiol), 17β-estradiol 17-benzoate (estradiol benzoate), and 17β-2-(1-adamantyl)estradiol (adamantyl estradiol) in 19F-labeled DPPC phospholipid multilamellar vesicles. Placement of the estrogen molecules in lipid bilayers is correlated with the differences in their neuroprotective potency.

KW - Estrogens

KW - Lipid bilayers

KW - Membranes

KW - Neuroprotection

KW - REDOR

KW - Solid-state NMR

UR - https://www.scopus.com/pages/publications/33644846396

U2 - 10.1002/ddr.20048

DO - 10.1002/ddr.20048

M3 - Article

AN - SCOPUS:33644846396

SN - 0272-4391

VL - 66

SP - 93

EP - 102

JO - Drug Development Research

JF - Drug Development Research

IS - 2

ER -

Mapping the locations of estradiol and potent neuroprotective analogues in phospholipid bilayers by REDOR

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this