Mapping the locations of estradiol and potent neuroprotective analogues in phospholipid bilayers by REDOR

Lynette Cegelski, Charles V. Rice, Robert D. O'Connor, Amy L. Caruano, Gregory P. Tochtrop, Zu Yun Cai, Douglas F. Covey, Jacob Schaefer

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Estrogens are potent antioxidants and neuroprotectants. They have become the focus of drug development efforts aimed at treating and preventing neuronal damage in stroke-related brain damage, Alzheimer's disease, and Parkinson's disease. 13C{31P} and 13C{19F} rotational-echo double-resonance NMR have been used to map the locations of 17β-estradiol (estradiol), 17β-estradiol 17-benzoate (estradiol benzoate), and 17β-2-(1-adamantyl)estradiol (adamantyl estradiol) in 19F-labeled DPPC phospholipid multilamellar vesicles. Placement of the estrogen molecules in lipid bilayers is correlated with the differences in their neuroprotective potency.

Original languageEnglish
Pages (from-to)93-102
Number of pages10
JournalDrug Development Research
Volume66
Issue number2
DOIs
StatePublished - Oct 2005

Keywords

  • Estrogens
  • Lipid bilayers
  • Membranes
  • Neuroprotection
  • REDOR
  • Solid-state NMR

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