Abstract
Estrogens are potent antioxidants and neuroprotectants. They have become the focus of drug development efforts aimed at treating and preventing neuronal damage in stroke-related brain damage, Alzheimer's disease, and Parkinson's disease. 13C{31P} and 13C{19F} rotational-echo double-resonance NMR have been used to map the locations of 17β-estradiol (estradiol), 17β-estradiol 17-benzoate (estradiol benzoate), and 17β-2-(1-adamantyl)estradiol (adamantyl estradiol) in 19F-labeled DPPC phospholipid multilamellar vesicles. Placement of the estrogen molecules in lipid bilayers is correlated with the differences in their neuroprotective potency.
Original language | English |
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Pages (from-to) | 93-102 |
Number of pages | 10 |
Journal | Drug Development Research |
Volume | 66 |
Issue number | 2 |
DOIs | |
State | Published - Oct 2005 |
Keywords
- Estrogens
- Lipid bilayers
- Membranes
- Neuroprotection
- REDOR
- Solid-state NMR