Mapping of the MYCL2 processed gene to Xq22-23 and identification of an additional L MYC-related sequence in Xq27.2

E. Redolfi; A. Pizzuti; A. Di Bacco; L. Susani; T. Labella; M. Affer; C. Montagna; R. Reinbold; S. Mumm; P. Vezzoni; I. Zucchi

doi:10.1016/S0014-5793(99)00243-4

Mapping of the MYCL2 processed gene to Xq22-23 and identification of an additional L MYC-related sequence in Xq27.2

E. Redolfi, A. Pizzuti, A. Di Bacco, L. Susani, T. Labella, M. Affer, C. Montagna, R. Reinbold, S. Mumm, P. Vezzoni, I. Zucchi

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Abstract

We report here the identification of a human genomic sequence from the q27.2 region of the X chromosome which shows a high homology to the L-MYC proto-oncogene. This sequence is not the MYCL2 homology, previously mapped to the long arm of the X chromosome at q22-qter by Morton et al., as we located the MYCL2-processed gene in Xq22-23, using a panel containing a combination of hybrid DNA carrying different portions of the human X chromosome. Based on computer analysis, the MYC-like sequence (MYCL3) is 98.2% identical to a portion of exon 3 of the MYCL1 gene and maps to the Xq27.2 region, between the DXS312 and DXS292 loci. Copyright (C) 1999 Federation of European Biochemical Societies.

Original language	English
Pages (from-to)	273-277
Number of pages	5
Journal	FEBS Letters
Volume	446
Issue number	2-3
DOIs	https://doi.org/10.1016/S0014-5793(99)00243-4
State	Published - Mar 12 1999

Keywords

Gene mapping
MYC homology
Xq27

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10.1016/S0014-5793(99)00243-4

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@article{9a26df14e7934ec9935bc496c06358e3,

title = "Mapping of the MYCL2 processed gene to Xq22-23 and identification of an additional L MYC-related sequence in Xq27.2",

abstract = "We report here the identification of a human genomic sequence from the q27.2 region of the X chromosome which shows a high homology to the L-MYC proto-oncogene. This sequence is not the MYCL2 homology, previously mapped to the long arm of the X chromosome at q22-qter by Morton et al., as we located the MYCL2-processed gene in Xq22-23, using a panel containing a combination of hybrid DNA carrying different portions of the human X chromosome. Based on computer analysis, the MYC-like sequence (MYCL3) is 98.2% identical to a portion of exon 3 of the MYCL1 gene and maps to the Xq27.2 region, between the DXS312 and DXS292 loci. Copyright (C) 1999 Federation of European Biochemical Societies.",

keywords = "Gene mapping, MYC homology, Xq27",

author = "E. Redolfi and A. Pizzuti and {Di Bacco}, A. and L. Susani and T. Labella and M. Affer and C. Montagna and R. Reinbold and S. Mumm and P. Vezzoni and I. Zucchi",

note = "Funding Information: We would like to thank Prof. Renato Dulbecco for his input and Victoria Starnes for typing the manuscript. We acknowledge the TIGEM Milano (Italy) for providing us with the Ben3B cell line. This manuscript is paper number 27 of the Genoma 2000/ITBA Project funded by Cariplo. This work is partially supported by Grant number E415 from Telethon to IZ. SM was supported by a fellowship from the Shriners Hospital for Children and NIH Grant HD33013.",

year = "1999",

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doi = "10.1016/S0014-5793(99)00243-4",

language = "English",

volume = "446",

pages = "273--277",

journal = "FEBS Letters",

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T1 - Mapping of the MYCL2 processed gene to Xq22-23 and identification of an additional L MYC-related sequence in Xq27.2

AU - Redolfi, E.

AU - Pizzuti, A.

AU - Di Bacco, A.

AU - Susani, L.

AU - Labella, T.

AU - Affer, M.

AU - Montagna, C.

AU - Reinbold, R.

AU - Mumm, S.

AU - Vezzoni, P.

AU - Zucchi, I.

N1 - Funding Information: We would like to thank Prof. Renato Dulbecco for his input and Victoria Starnes for typing the manuscript. We acknowledge the TIGEM Milano (Italy) for providing us with the Ben3B cell line. This manuscript is paper number 27 of the Genoma 2000/ITBA Project funded by Cariplo. This work is partially supported by Grant number E415 from Telethon to IZ. SM was supported by a fellowship from the Shriners Hospital for Children and NIH Grant HD33013.

PY - 1999/3/12

Y1 - 1999/3/12

N2 - We report here the identification of a human genomic sequence from the q27.2 region of the X chromosome which shows a high homology to the L-MYC proto-oncogene. This sequence is not the MYCL2 homology, previously mapped to the long arm of the X chromosome at q22-qter by Morton et al., as we located the MYCL2-processed gene in Xq22-23, using a panel containing a combination of hybrid DNA carrying different portions of the human X chromosome. Based on computer analysis, the MYC-like sequence (MYCL3) is 98.2% identical to a portion of exon 3 of the MYCL1 gene and maps to the Xq27.2 region, between the DXS312 and DXS292 loci. Copyright (C) 1999 Federation of European Biochemical Societies.

AB - We report here the identification of a human genomic sequence from the q27.2 region of the X chromosome which shows a high homology to the L-MYC proto-oncogene. This sequence is not the MYCL2 homology, previously mapped to the long arm of the X chromosome at q22-qter by Morton et al., as we located the MYCL2-processed gene in Xq22-23, using a panel containing a combination of hybrid DNA carrying different portions of the human X chromosome. Based on computer analysis, the MYC-like sequence (MYCL3) is 98.2% identical to a portion of exon 3 of the MYCL1 gene and maps to the Xq27.2 region, between the DXS312 and DXS292 loci. Copyright (C) 1999 Federation of European Biochemical Societies.

KW - Gene mapping

KW - MYC homology

KW - Xq27

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DO - 10.1016/S0014-5793(99)00243-4

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AN - SCOPUS:0033002354

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JF - FEBS Letters

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ER -

Mapping of the MYCL2 processed gene to Xq22-23 and identification of an additional L MYC-related sequence in Xq27.2

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Keywords

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