Mapping of the HLA locus controlling C2 structural variants and linkage disequilibrium between alleles C22 and Bw15

T. Meo; Marietta Bernoc; D. Bernoco; R. Ceppellini; J. Atkinson

doi:10.1002/eji.1830061216

Mapping of the HLA locus controlling C2 structural variants and linkage disequilibrium between alleles C2² and Bw15

T. Meo, Marietta Bernoc, D. Bernoco, R. Ceppellini, J. Atkinson

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Abstract

The newly discovered polymorphism of human C2 protein analyzed by isoelectric focusing is controlled by a locus closely linked to HLA. An informative cross‐over family (HLA: A×C) indicates that this locus maps on the C side of the region. Population and family studies have shown that the C2² variant is significantly associated on the haplotype with alleles Bw15 and Cw3. The fact that the “deficient” C2 mutant is in linkage disequilibrium with other HLA antigens, suggests that C2² and C2⁰, here tentatively considered alleles of the same locus, are not directly related by descent.

Original language	English
Pages (from-to)	916-919
Number of pages	4
Journal	European Journal of Immunology
Volume	6
Issue number	12
DOIs	https://doi.org/10.1002/eji.1830061216
State	Published - Dec 1976

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title = "Mapping of the HLA locus controlling C2 structural variants and linkage disequilibrium between alleles C22 and Bw15",

abstract = "The newly discovered polymorphism of human C2 protein analyzed by isoelectric focusing is controlled by a locus closely linked to HLA. An informative cross‐over family (HLA: A×C) indicates that this locus maps on the C side of the region. Population and family studies have shown that the C22 variant is significantly associated on the haplotype with alleles Bw15 and Cw3. The fact that the “deficient” C2 mutant is in linkage disequilibrium with other HLA antigens, suggests that C22 and C20, here tentatively considered alleles of the same locus, are not directly related by descent.",

author = "T. Meo and Marietta Bernoc and D. Bernoco and R. Ceppellini and J. Atkinson",

year = "1976",

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journal = "European Journal of Immunology",

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T1 - Mapping of the HLA locus controlling C2 structural variants and linkage disequilibrium between alleles C22 and Bw15

AU - Meo, T.

AU - Bernoc, Marietta

AU - Bernoco, D.

AU - Ceppellini, R.

AU - Atkinson, J.

PY - 1976/12

Y1 - 1976/12

N2 - The newly discovered polymorphism of human C2 protein analyzed by isoelectric focusing is controlled by a locus closely linked to HLA. An informative cross‐over family (HLA: A×C) indicates that this locus maps on the C side of the region. Population and family studies have shown that the C22 variant is significantly associated on the haplotype with alleles Bw15 and Cw3. The fact that the “deficient” C2 mutant is in linkage disequilibrium with other HLA antigens, suggests that C22 and C20, here tentatively considered alleles of the same locus, are not directly related by descent.

AB - The newly discovered polymorphism of human C2 protein analyzed by isoelectric focusing is controlled by a locus closely linked to HLA. An informative cross‐over family (HLA: A×C) indicates that this locus maps on the C side of the region. Population and family studies have shown that the C22 variant is significantly associated on the haplotype with alleles Bw15 and Cw3. The fact that the “deficient” C2 mutant is in linkage disequilibrium with other HLA antigens, suggests that C22 and C20, here tentatively considered alleles of the same locus, are not directly related by descent.

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U2 - 10.1002/eji.1830061216

DO - 10.1002/eji.1830061216

M3 - Article

AN - SCOPUS:0017053597

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VL - 6

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EP - 919

JO - European Journal of Immunology

JF - European Journal of Immunology

IS - 12

ER -

Mapping of the HLA locus controlling C2 structural variants and linkage disequilibrium between alleles C2² and Bw15

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