Mapping Mammary Tumor Traits in the Rat

Michael J. Flister, Amit Joshi, Carmen Bergom, Hallgeir Rui

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

For nearly a century, the rat has served as a key model for studying the pathophysiology and genetic risk modifiers of breast cancer. Rat mammary tumors that initiate after exposure to carcinogens or estrogens closely resemble the etiological, histopathological, and genomic features of human breast cancer. Recent developments in genome-editing techniques in the rat have also enabled the development of sophisticated models for identifying the genetic modifiers of the nonmalignant tumor microenvironment that contribute to the formation, progression, and outcome of breast cancer. In this protocol review, we discuss the current methodologies for the three genetic mapping techniques in the rat that are widely used for identifying and testing the heritable genetic modifiers of breast cancer.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages249-267
Number of pages19
DOIs
StatePublished - 2019

Publication series

NameMethods in Molecular Biology
Volume2018
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

Keywords

  • Breast cancer
  • Genetics
  • Rat
  • Tumor microenvironment

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