Mapping functional connectivity using cerebral blood flow in the mouse brain

Karla M. Bergonzi, Adam Q. Bauer, Patrick W. Wright, Joseph P. Culver

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Brain function can be assessed from resting-state functional connectivity (rs-fc) maps, most commonly created by analyzing the dynamics of cerebral hemoglobin concentration. Here, we develop the use of Laser Speckle Contrast Imaging (LSCI) for mapping rs-fc using cerebral blood flow (CBF) dynamics. Because LSCI is intrinsically noisy, we used spatial and temporal averaging to sufficiently raise the signal-to-noise ratio for observing robust functional networks. Although CBF-based rs-fc maps in healthy mice are qualitatively similar to simultaneously-acquired HbO 2 -based maps, some quantitative regional differences were observed. These combined flow/concentration maps might help clarify mechanisms involved in network disruption during disease.

Original languageEnglish
Pages (from-to)367-370
Number of pages4
JournalJournal of Perinatology
Issue number3
StatePublished - Mar 1 2015


  • brain imaging
  • cortical mapping
  • intrinsic optical imaging
  • neurovascular coupling


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