Mannogen-ing Central Carbon Metabolism by Leishmania

Kai Zhang; Stephen M. Beverley

doi:10.1016/j.pt.2019.10.001

Mannogen-ing Central Carbon Metabolism by Leishmania

Kai Zhang
, Stephen M. Beverley

Research output: Contribution to journal › Short survey › peer-review

3 Scopus citations

Abstract

Leishmania parasites synthesize mannogens, a unique type of storage carbohydrate, from finely tuned interactions between synthesis and degradation by a family of mannosyltransferase/phosphorylases (MTPs) newly discovered by Sernee et al. The crucial roles of mannogen in regulating central carbon metabolism and in vivo virulence suggest the potential of MTPs as promising drug targets.

Original language	English
Pages (from-to)	947-949
Number of pages	3
Journal	Trends in Parasitology
Volume	35
Issue number	12
DOIs	https://doi.org/10.1016/j.pt.2019.10.001
State	Published - Dec 2019

Keywords

dual-activity mannosyltransferase/phosphorylase
horizontal gene transfer
reservoir carbohydrate
trypanosomatid protozoan parasite
virulence

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10.1016/j.pt.2019.10.001

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title = "Mannogen-ing Central Carbon Metabolism by Leishmania",

abstract = "Leishmania parasites synthesize mannogens, a unique type of storage carbohydrate, from finely tuned interactions between synthesis and degradation by a family of mannosyltransferase/phosphorylases (MTPs) newly discovered by Sernee et al. The crucial roles of mannogen in regulating central carbon metabolism and in vivo virulence suggest the potential of MTPs as promising drug targets.",

keywords = "dual-activity mannosyltransferase/phosphorylase, horizontal gene transfer, reservoir carbohydrate, trypanosomatid protozoan parasite, virulence",

author = "Kai Zhang and Beverley, \{Stephen M.\}",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",

year = "2019",

month = dec,

doi = "10.1016/j.pt.2019.10.001",

language = "English",

volume = "35",

pages = "947--949",

journal = "Trends in Parasitology",

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T1 - Mannogen-ing Central Carbon Metabolism by Leishmania

AU - Zhang, Kai

AU - Beverley, Stephen M.

PY - 2019/12

Y1 - 2019/12

N2 - Leishmania parasites synthesize mannogens, a unique type of storage carbohydrate, from finely tuned interactions between synthesis and degradation by a family of mannosyltransferase/phosphorylases (MTPs) newly discovered by Sernee et al. The crucial roles of mannogen in regulating central carbon metabolism and in vivo virulence suggest the potential of MTPs as promising drug targets.

AB - Leishmania parasites synthesize mannogens, a unique type of storage carbohydrate, from finely tuned interactions between synthesis and degradation by a family of mannosyltransferase/phosphorylases (MTPs) newly discovered by Sernee et al. The crucial roles of mannogen in regulating central carbon metabolism and in vivo virulence suggest the potential of MTPs as promising drug targets.

KW - dual-activity mannosyltransferase/phosphorylase

KW - horizontal gene transfer

KW - reservoir carbohydrate

KW - trypanosomatid protozoan parasite

KW - virulence

UR - https://www.scopus.com/pages/publications/85074409595

U2 - 10.1016/j.pt.2019.10.001

DO - 10.1016/j.pt.2019.10.001

M3 - Short survey

C2 - 31662278

AN - SCOPUS:85074409595

SN - 1471-4922

VL - 35

SP - 947

EP - 949

JO - Trends in Parasitology

JF - Trends in Parasitology

IS - 12

ER -

Mannogen-ing Central Carbon Metabolism by Leishmania

Abstract

Keywords

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