Manipulating Light for the Detection of Viruses in Resource-Limited Settings

Abraham J. Qavi, Qisheng Jiang, M. Javad Aman, Hong Vu, Larry Zetlin, John M. Dye, Jeffrey W. Froude, Daisy W. Leung, Frederick Holtsberg, Scott L. Crick, Gaya Amarasinghe

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Neglected tropical diseases, including filoviruses, constitute a class of diseases affecting some of the most impoverished and vulnerable populations worldwide. Despite their significant impact, there is a pressing need for diagnostics that can effectively and rapidly detect pathogens in field settings. Herein, we present a portable diagnostic platform leveraging plasmonic fluors and lateral flow assays for the detection of filoviruses. Plasmonic fluors are a class of engineered, ultrabright fluorescent probes whose versatility and amenability towards use in a variety of diagnostics is a major clinical strength. Our resulting assay has a rapid turnaround time and sensitivities amenable for field deployment.

Original languageEnglish
Title of host publicationFrontiers in Biological Detection
Subtitle of host publicationFrom Nanosensors to Systems XVI
EditorsAmos Danielli, Benjamin L. Miller, Sharon M. Weiss
PublisherSPIE
ISBN (Electronic)9781510669819
DOIs
StatePublished - 2024
EventFrontiers in Biological Detection: From Nanosensors to Systems XVI 2024 - San Francisco, United States
Duration: Jan 28 2024Jan 29 2024

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume12861
ISSN (Print)1605-7422

Conference

ConferenceFrontiers in Biological Detection: From Nanosensors to Systems XVI 2024
Country/TerritoryUnited States
CitySan Francisco
Period01/28/2401/29/24

Keywords

  • Diagnostics
  • neglected tropical diseases
  • pathogens
  • plasmonics

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