TY - JOUR
T1 - Management of the late ocular sequelae of Stevens-Johnson syndrome
AU - Wall, Vicki
AU - Yen, Michael T.
AU - Yang, Mei Chuan
AU - Huang, Andrew J.W.
AU - Pflugfelder, Stephen C.
N1 - Funding Information:
From the 1Ocular Surface Center, Department of Ophthalmology, Baylor College of Medicine, Houston, TX, 2Department of Ophthalmology, University of Minnesota School of Medicine, Minneapolis, MN Supported by NEI Grant EY11915, an unrestricted grant from Research to Prevent Blindness, The Oshman Foundation and The William Stamps Farish Fund.
PY - 2003/10
Y1 - 2003/10
N2 - The acute conjunctivitis seen initially in Stevens-Johnson syndrome is followed by a cicatricial phase, which often leads to severe ocular surface disease and visual morbidity. Manifestations include keratinization of the conjunctiva, lid margins, and lacrimal and meibomian ducts, resulting in an unstable tear film and mechanical trauma to the conjunctiva and cornea with blinking. Limbal stem cell deficiency is the most vision-threatening sequela of Stevens-Johnson syndrome, as it causes corneal neovascularization, chronic corneal inflammation, and an irregular corneal epithelium. Management of late sequelae often requires a multipronged approach, including strategies for ocular surface protection, ocular surface support, and ocular surface reconstruction. In this review, established therapies, as well as new experimental therapies, are discussed.
AB - The acute conjunctivitis seen initially in Stevens-Johnson syndrome is followed by a cicatricial phase, which often leads to severe ocular surface disease and visual morbidity. Manifestations include keratinization of the conjunctiva, lid margins, and lacrimal and meibomian ducts, resulting in an unstable tear film and mechanical trauma to the conjunctiva and cornea with blinking. Limbal stem cell deficiency is the most vision-threatening sequela of Stevens-Johnson syndrome, as it causes corneal neovascularization, chronic corneal inflammation, and an irregular corneal epithelium. Management of late sequelae often requires a multipronged approach, including strategies for ocular surface protection, ocular surface support, and ocular surface reconstruction. In this review, established therapies, as well as new experimental therapies, are discussed.
KW - Amniotic membrane transplantation
KW - Autologous serum
KW - Cyclosporine A
KW - Dermatologic disease
KW - Inflammation
KW - Keratinization
KW - Keratoprosthesis
KW - Limbal stem cell transplantation
KW - Mucous membrane transplantation
KW - Penetrating keratoplasty
KW - Punctal occlusion
KW - Salivary gland autotransplantation
KW - Stevens-Johnson syndrome
KW - Subcutaneous abdominal artificial tear reservoir
KW - Therapeutic contact lenses
KW - Vitamin A
UR - http://www.scopus.com/inward/record.url?scp=24644496219&partnerID=8YFLogxK
U2 - 10.1016/S1542-0124(12)70014-9
DO - 10.1016/S1542-0124(12)70014-9
M3 - Article
C2 - 17075650
AN - SCOPUS:24644496219
VL - 1
SP - 192
EP - 201
JO - Ocular Surface
JF - Ocular Surface
SN - 1542-0124
IS - 4
ER -