Management of the late ocular sequelae of Stevens-Johnson syndrome

Vicki Wall, Michael T. Yen, Mei Chuan Yang, Andrew J.W. Huang, Stephen C. Pflugfelder

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

The acute conjunctivitis seen initially in Stevens-Johnson syndrome is followed by a cicatricial phase, which often leads to severe ocular surface disease and visual morbidity. Manifestations include keratinization of the conjunctiva, lid margins, and lacrimal and meibomian ducts, resulting in an unstable tear film and mechanical trauma to the conjunctiva and cornea with blinking. Limbal stem cell deficiency is the most vision-threatening sequela of Stevens-Johnson syndrome, as it causes corneal neovascularization, chronic corneal inflammation, and an irregular corneal epithelium. Management of late sequelae often requires a multipronged approach, including strategies for ocular surface protection, ocular surface support, and ocular surface reconstruction. In this review, established therapies, as well as new experimental therapies, are discussed.

Original languageEnglish
Pages (from-to)192-201
Number of pages10
JournalOcular Surface
Volume1
Issue number4
DOIs
StatePublished - Oct 2003
Externally publishedYes

Keywords

  • Amniotic membrane transplantation
  • Autologous serum
  • Cyclosporine A
  • Dermatologic disease
  • Inflammation
  • Keratinization
  • Keratoprosthesis
  • Limbal stem cell transplantation
  • Mucous membrane transplantation
  • Penetrating keratoplasty
  • Punctal occlusion
  • Salivary gland autotransplantation
  • Stevens-Johnson syndrome
  • Subcutaneous abdominal artificial tear reservoir
  • Therapeutic contact lenses
  • Vitamin A

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