Management of recurrent testicular germ cell tumors

Guru Sonpavde, Thomas E. Hutson, Bruce J. Roth

Research output: Contribution to journalReview article

21 Scopus citations

Abstract

Although front-line chemotherapy cures most men with testicular germ cell tumors, salvage therapy is still important in a small but significant minority. Second-line conventional-dose or high-dose chemotherapy with stem cell rescue may cure 25%-50% of patients. New chemotherapeutic agents, including the taxanes gemcitabine and oxaliplatin, have added to the therapeutic armamentarium. Salvage surgical resection has an important role in selected patients. Cisplatin-refractory patients have a poor prognosis with current therapy, and novel chemotherapeutic and biologic agents need to be discovered for such patients.

Original languageEnglish
Pages (from-to)51-61
Number of pages11
JournalOncologist
Volume12
Issue number1
DOIs
StatePublished - Jan 29 2007
Externally publishedYes

Keywords

  • Germ cell tumors
  • Salvage

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