TY - JOUR
T1 - Management of Clostridioides (formerly Clostridium) difficile infection (CDI) in solid organ transplant recipients
T2 - Guidelines from the American Society of Transplantation Community of Practice
AU - on behalf of the AST ID Community of Practice
AU - Mullane, Kathleen M.
AU - Dubberke, Erik R.
N1 - Funding Information:
This manuscript was modified from the Guidelines included in the 3rd Edition of the AST Infectious Diseases Guidelines written by Erik R. Dubberke and Steven D. Burdette published in the American Journal of Transplantation 2013; 13 (Suppl 4): 42-49, and endorsed by the American Society of Transplantation.
Publisher Copyright:
© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
PY - 2019/9/1
Y1 - 2019/9/1
N2 - These updated guidelines from the American Society of Transplantation Infectious Diseases Community of Practice address the prevention and management of Clostridium difficile infection in solid organ transplant (SOT) recipients. Clostridioides (formerly Clostridium) difficile infection (CDI) is among the most common hospital acquired infections. In SOT recipients, the incidence of CDI varies by type and number or organs transplanted. While a meta-analysis of published literature found the prevalence of postoperative CDI in the general surgical population to be approximately 0.51%, the prevalence of CDI that is seen in the solid organ transplant population ranges from a low of 3.2% in the pancreatic transplant population to 12.7% in those receiving multiple organ transplants. There are no randomized, controlled trials evaluating the management of CDI in the SOT population. Herein is a review and summary of the currently available literature that has been synthesized into updated treatment guidelines for the management of CDI in the SOT population.
AB - These updated guidelines from the American Society of Transplantation Infectious Diseases Community of Practice address the prevention and management of Clostridium difficile infection in solid organ transplant (SOT) recipients. Clostridioides (formerly Clostridium) difficile infection (CDI) is among the most common hospital acquired infections. In SOT recipients, the incidence of CDI varies by type and number or organs transplanted. While a meta-analysis of published literature found the prevalence of postoperative CDI in the general surgical population to be approximately 0.51%, the prevalence of CDI that is seen in the solid organ transplant population ranges from a low of 3.2% in the pancreatic transplant population to 12.7% in those receiving multiple organ transplants. There are no randomized, controlled trials evaluating the management of CDI in the SOT population. Herein is a review and summary of the currently available literature that has been synthesized into updated treatment guidelines for the management of CDI in the SOT population.
KW - Clostridium difficile
KW - antibiotic-associated diarrhea
KW - nosocomial infection
KW - pseudomembranous colitis
KW - solid organ transplant
UR - http://www.scopus.com/inward/record.url?scp=85068126018&partnerID=8YFLogxK
U2 - 10.1111/ctr.13564
DO - 10.1111/ctr.13564
M3 - Article
C2 - 31002420
AN - SCOPUS:85068126018
SN - 0902-0063
VL - 33
JO - Clinical Transplantation
JF - Clinical Transplantation
IS - 9
M1 - e13564
ER -