Management of anticoagulation and hemostasis for pediatric extracorporeal membrane oxygenation

Arun Saini, Philip C. Spinella

Research output: Contribution to journalReview articlepeer-review

40 Scopus citations

Abstract

Compared to in situ vascular physiology where pro and anti-hemostatic processes are in balance to maintain hemostasis, the use of ECMO in a critically ill child increases the risk of hemorrhagic or thromboembolic events due to a perturbation in the balance inherent of this complex system. The ECMO circuit has pro-hemostatic effects due to contact activation of hemostasis and inflammatory pathways. In addition, the critical illness of the child can cause dysregulation of hemostasis that may shift between hyper and hypocoagulable states over time.

Original languageEnglish
Pages (from-to)655-673
Number of pages19
JournalClinics in Laboratory Medicine
Volume34
Issue number3
DOIs
StatePublished - Sep 2014

Keywords

  • Anticoagulation
  • Congenital heart defect
  • Extracorporeal membrane oxygenation
  • Heparin
  • Platelet function
  • Thromboelastography

Fingerprint

Dive into the research topics of 'Management of anticoagulation and hemostasis for pediatric extracorporeal membrane oxygenation'. Together they form a unique fingerprint.

Cite this