Management of anticoagulant-related intracranial hemorrhage: An evidence-based review

Bappaditya Ray, Salah G. Keyrouz

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations


The increased use of anticoagulants for the prevention and treatment of thromboembolic diseases has led to a rising incidence of anticoagulant-related intracranial hemorrhage (AICH) in the aging western population. High mortality accompanies this form of hemorrhagic stroke, and significant and debilitating long-term consequences plague survivors. Although management guidelines for such hemorrhages are available for the older generation anticoagulants, they are still lacking for newer agents, which are becoming popular among physicians. Supportive care, including blood pressure control, and reversal of anticoagulation remain the cornerstone of acute management of AICH. Prothrombin complex concentrates are gaining popularity over fresh frozen plasma, and reversal agents for newer anticoagulation agents are being developed. Surgical interventions are options fraught with complications, and are decided on a case-by-case basis. Our current state of understanding of this condition and its management is insufficient. This deficit calls for more population-based studies and therapeutic trials to better evaluate risk factors for, and to prevent and treat AICH.

Original languageEnglish
Article number223
JournalCritical Care
Issue number3
StatePublished - May 23 2014


Dive into the research topics of 'Management of anticoagulant-related intracranial hemorrhage: An evidence-based review'. Together they form a unique fingerprint.

Cite this