TY - JOUR
T1 - Management of Acute Asthma in Childhood
T2 - A Randomized Evaluation of β-Adrenergic Agents
AU - Schwartz, Alan L.
AU - Lipton, Jeffrey M.
AU - Warburton, David
AU - Johnson, Lawrence B.
AU - Twarog, Frank J.
PY - 1980/5
Y1 - 1980/5
N2 - We examined the efficacy of several β-adrenergic agents commonly used to treat asthma and evaluated the optimum route of administration. Two hundred and sixty-nine persons aged 5 to 21 years who came to the emergency ward while suffering from acute asthma were treated with either (1) inhalation isoetharine hydrochloride or (2) subcutaneous epinephrine or terbutaline sulfate. Patients were evaluated using clinical scores and pulmonary function tests and were monitored for adverse side effects. Regardless of mode of therapy, the acute attack was either treated successfully, terminated in hospital admission, or required further therapy within 24 hours in a comparable number of patients. Adverse side effects were more common with terbutaline sulfate than with either epinephrine or isoetharine in the doses used. Thus, inhalation of β-adrenergic agents is as effective as subcutaneous administration in the treatment of acute asthma in childhood.
AB - We examined the efficacy of several β-adrenergic agents commonly used to treat asthma and evaluated the optimum route of administration. Two hundred and sixty-nine persons aged 5 to 21 years who came to the emergency ward while suffering from acute asthma were treated with either (1) inhalation isoetharine hydrochloride or (2) subcutaneous epinephrine or terbutaline sulfate. Patients were evaluated using clinical scores and pulmonary function tests and were monitored for adverse side effects. Regardless of mode of therapy, the acute attack was either treated successfully, terminated in hospital admission, or required further therapy within 24 hours in a comparable number of patients. Adverse side effects were more common with terbutaline sulfate than with either epinephrine or isoetharine in the doses used. Thus, inhalation of β-adrenergic agents is as effective as subcutaneous administration in the treatment of acute asthma in childhood.
UR - http://www.scopus.com/inward/record.url?scp=0018874988&partnerID=8YFLogxK
U2 - 10.1001/archpedi.1980.02130170024009
DO - 10.1001/archpedi.1980.02130170024009
M3 - Article
C2 - 6990745
AN - SCOPUS:0018874988
SN - 0002-922X
VL - 134
SP - 474
EP - 478
JO - American Journal of Diseases of Children
JF - American Journal of Diseases of Children
IS - 5
ER -