@inproceedings{f1a872994a50479b96aef5560d048363,
title = "Mammographic phenotypes of breast cancer risk driven by breast anatomy",
abstract = "Image-derived features of breast parenchymal texture patterns have emerged as promising risk factors for breast cancer, paving the way towards personalized recommendations regarding women's cancer risk evaluation and screening. The main steps to extract texture features of the breast parenchyma are the selection of regions of interest (ROIs) where texture analysis is performed, the texture feature calculation and the texture feature summarization in case of multiple ROIs. In this study, we incorporate breast anatomy in these three key steps by (a) introducing breast anatomical sampling for the definition of ROIs, (b) texture feature calculation aligned with the structure of the breast and (c) weighted texture feature summarization considering the spatial position and the underlying tissue composition of each ROI. We systematically optimize this novel framework for parenchymal tissue characterization in a case-control study with digital mammograms from 424 women. We also compare the proposed approach with a conventional methodology, not considering breast anatomy, recently shown to enhance the case-control discriminatory capacity of parenchymal texture analysis. The case-control classification performance is assessed using elastic-net regression with 5-fold cross validation, where the evaluation measure is the area under the curve (AUC) of the receiver operating characteristic. Upon optimization, the proposed breast-anatomy-driven approach demonstrated a promising case-control classification performance (AUC=0.87). In the same dataset, the performance of conventional texture characterization was found to be significantly lower (AUC=0.80, DeLong's test p-value<0.05). Our results suggest that breast anatomy may further leverage the associations of parenchymal texture features with breast cancer, and may therefore be a valuable addition in pipelines aiming to elucidate quantitative mammographic phenotypes of breast cancer risk.",
keywords = "Breast anatomy, Breast cancer risk, Breast density, Digital mammography, Parenchymal texture",
author = "Aimilia Gastounioti and Andrew Oustimov and Hsieh, {Meng Kang} and Lauren Pantalone and Conant, {Emily F.} and Despina Kontos",
note = "Publisher Copyright: {\textcopyright} 2017 SPIE.; Medical Imaging 2017: Computer-Aided Diagnosis ; Conference date: 13-02-2017 Through 16-02-2017",
year = "2017",
doi = "10.1117/12.2254630",
language = "English",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Petrick, {Nicholas A.} and Armato, {Samuel G.}",
booktitle = "Medical Imaging 2017",
}