Malignant Transformation of an Aneurysmal Bone Cyst to Fibroblastic Osteosarcoma

Akash P. Kansagra, Jennifer J. Wan, Kavi K. Devulapalli, Andrew E. Horvai, Richard J. O'Donnell, Thomas M. Link

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Aneurysmal bone cysts are uncommon primary bone tumors typically regarded as histologically and clinically benign. Malignant transformation of these lesions occurs almost exclusively in the context of prior radiation exposure. However, 4 cases of an osteosarcoma developing without prior radiation exposure have been reported. In this article, we report a fifth case of degeneration of an aneurysmal bone cyst to a fibroblastic osteosarcoma. In addition to reviewing the earlier cases, we describe the radiologic, pathologic, and immunohistochemical basis of this diagnosis.

Original languageEnglish
Pages (from-to)E367-E372
JournalAmerican journal of orthopedics (Belle Mead, N.J.)
Issue number6
StatePublished - Oct 1 2016


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