TY - JOUR
T1 - Malignant Transformation of an Aneurysmal Bone Cyst to Fibroblastic Osteosarcoma
AU - Kansagra, Akash P.
AU - Wan, Jennifer J.
AU - Devulapalli, Kavi K.
AU - Horvai, Andrew E.
AU - O'Donnell, Richard J.
AU - Link, Thomas M.
PY - 2016/10/1
Y1 - 2016/10/1
N2 - Aneurysmal bone cysts are uncommon primary bone tumors typically regarded as histologically and clinically benign. Malignant transformation of these lesions occurs almost exclusively in the context of prior radiation exposure. However, 4 cases of an osteosarcoma developing without prior radiation exposure have been reported. In this article, we report a fifth case of degeneration of an aneurysmal bone cyst to a fibroblastic osteosarcoma. In addition to reviewing the earlier cases, we describe the radiologic, pathologic, and immunohistochemical basis of this diagnosis.
AB - Aneurysmal bone cysts are uncommon primary bone tumors typically regarded as histologically and clinically benign. Malignant transformation of these lesions occurs almost exclusively in the context of prior radiation exposure. However, 4 cases of an osteosarcoma developing without prior radiation exposure have been reported. In this article, we report a fifth case of degeneration of an aneurysmal bone cyst to a fibroblastic osteosarcoma. In addition to reviewing the earlier cases, we describe the radiologic, pathologic, and immunohistochemical basis of this diagnosis.
UR - http://www.scopus.com/inward/record.url?scp=85021852608&partnerID=8YFLogxK
M3 - Article
C2 - 27737291
AN - SCOPUS:85021852608
SN - 1078-4519
VL - 45
SP - E367-E372
JO - American journal of orthopedics (Belle Mead, N.J.)
JF - American journal of orthopedics (Belle Mead, N.J.)
IS - 6
ER -