TY - JOUR
T1 - Malignant Transformation of a Giant Cell Tumor of Bone Treated with Denosumab A Case Report
AU - Park, Andrew
AU - Cipriano, Cara A.
AU - Hill, Kirk
AU - Kyriakos, Michael
AU - McDonald, Douglas J.
N1 - Publisher Copyright:
© 2016 BY THE JOURNAL OF BONE AND JOINT SURGERY, INCORPORATED.
PY - 2016/9/14
Y1 - 2016/9/14
N2 - Case: Giant cell tumor (GCT) of bone was first described almost 200 years ago, but the optimal treatment continues to evolve. We present a patient with a pelvic GCT who was treated with embolization, 20 months of denosumab therapy, and resection. Histologically, the tumor consisted of degenerated GCT, bone, and fibrous tissue. After 7 months, the patient was found to have osteosarcoma at the site of the initial lesion as well as pulmonary metastases. Conclusion: The apparent malignant transformation of a GCT of bone treated initially with denosumab indicates that close follow-up is warranted.
AB - Case: Giant cell tumor (GCT) of bone was first described almost 200 years ago, but the optimal treatment continues to evolve. We present a patient with a pelvic GCT who was treated with embolization, 20 months of denosumab therapy, and resection. Histologically, the tumor consisted of degenerated GCT, bone, and fibrous tissue. After 7 months, the patient was found to have osteosarcoma at the site of the initial lesion as well as pulmonary metastases. Conclusion: The apparent malignant transformation of a GCT of bone treated initially with denosumab indicates that close follow-up is warranted.
UR - http://www.scopus.com/inward/record.url?scp=85042130660&partnerID=8YFLogxK
U2 - 10.2106/JBJS.CC.16.00024
DO - 10.2106/JBJS.CC.16.00024
M3 - Article
C2 - 29252655
AN - SCOPUS:85042130660
SN - 2160-3251
VL - 6
JO - JBJS case connector
JF - JBJS case connector
IS - 3
M1 - e78
ER -