TY - JOUR
T1 - Malignant small cell tumor of the thoracopulmonary region in childhood. A distinctive clinicopathologic entity of uncertain histogenesis
AU - Askin, Frederic B.
AU - Rosai, Juan
AU - Sibley, Richard K.
AU - Dehner, Louis P.
AU - McAlister, William H.
PY - 1979/6
Y1 - 1979/6
N2 - This report describes a unique clinicopathologic entity characterized as a malignant small cell tumor of the thoracopulmonary region in 20 children and adolescents (average age 14.5 years). There was a female predilection (75%) for this tumor which appeared to originate in the soft tissues of the chest wall or the peripheral lung. The neoplasm tended to recur locally and did not seem to disseminate as widely as some of the other small cell tumors of childhood (rhabdomyosarcoma, Ewing's sarcoma, neuroblastoma and malignant lymphoma). However, the median survival was only 8 months. Electron microscopy of 3 cases suggested a neuroepithelial derivation, but, at the present, the histogenesis remains a subject for further investigation.
AB - This report describes a unique clinicopathologic entity characterized as a malignant small cell tumor of the thoracopulmonary region in 20 children and adolescents (average age 14.5 years). There was a female predilection (75%) for this tumor which appeared to originate in the soft tissues of the chest wall or the peripheral lung. The neoplasm tended to recur locally and did not seem to disseminate as widely as some of the other small cell tumors of childhood (rhabdomyosarcoma, Ewing's sarcoma, neuroblastoma and malignant lymphoma). However, the median survival was only 8 months. Electron microscopy of 3 cases suggested a neuroepithelial derivation, but, at the present, the histogenesis remains a subject for further investigation.
UR - http://www.scopus.com/inward/record.url?scp=0018648499&partnerID=8YFLogxK
U2 - 10.1002/1097-0142(197906)43:6<2438::AID-CNCR2820430640>3.0.CO;2-9
DO - 10.1002/1097-0142(197906)43:6<2438::AID-CNCR2820430640>3.0.CO;2-9
M3 - Article
C2 - 222426
AN - SCOPUS:0018648499
SN - 0008-543X
VL - 43
SP - 2438
EP - 2451
JO - Cancer
JF - Cancer
IS - 6
ER -