TY - JOUR
T1 - Malaria impairs T cell clustering and immune priming despite normal signal 1 from dendritic cells
AU - Millington, Owain R.
AU - Gibson, Vivienne B.
AU - Rush, Catherine M.
AU - Zinselmeyer, Bernd H.
AU - Phillips, R. Stephen
AU - Garside, Paul
AU - Brewer, James M.
PY - 2007/10
Y1 - 2007/10
N2 - Interactions between antigen-presenting dendritic cells (DCs) and T cells are essential for the induction of an immune response. However, during malaria infection, DC function is compromised and immune responses against parasite and heterologous antigens are reduced. Here, we demonstrate that malaria infection or the parasite pigment hemozoin inhibits T cell and DC interactions both in vitro and in vivo, while signal 1 intensity remains unaltered. This altered cellular behaviour is associated with the suppression of DC costimulatory activity and functional T cell responses, potentially explaining why immunity is reduced during malaria infection.
AB - Interactions between antigen-presenting dendritic cells (DCs) and T cells are essential for the induction of an immune response. However, during malaria infection, DC function is compromised and immune responses against parasite and heterologous antigens are reduced. Here, we demonstrate that malaria infection or the parasite pigment hemozoin inhibits T cell and DC interactions both in vitro and in vivo, while signal 1 intensity remains unaltered. This altered cellular behaviour is associated with the suppression of DC costimulatory activity and functional T cell responses, potentially explaining why immunity is reduced during malaria infection.
UR - http://www.scopus.com/inward/record.url?scp=36049031736&partnerID=8YFLogxK
U2 - 10.1371/journal.ppat.0030143
DO - 10.1371/journal.ppat.0030143
M3 - Article
C2 - 17937497
AN - SCOPUS:36049031736
SN - 1553-7366
VL - 3
SP - 1380
EP - 1387
JO - PLoS pathogens
JF - PLoS pathogens
IS - 10
ER -