Making a firm decision: Multifaceted regulation of cell fate in the early mouse embryo

Magdalena Zernicka-Goetz, Samantha A. Morris, Alexander W. Bruce

Research output: Contribution to journalReview article

201 Scopus citations

Abstract

The preimplantation mammalian embryo offers a striking opportunity to address the question of how and why apparently identical cells take on separate fates. Two cell fate decisions are taken before the embryo implants; these decisions set apart a group of pluripotent cells, progenitors for the future body, from the distinct extraembryonic lineages of trophectoderm and primitive endoderm. New molecular, cellular and developmental insights reveal the interplay of transcriptional regulation, epigenetic modifications, cell position and cell polarity in these two fate decisions in the mouse. We discuss how mechanisms proposed in previously distinct models might work in concert to progressively reinforce cell fate decisions through feedback loops.

Original languageEnglish
Pages (from-to)467-477
Number of pages11
JournalNature Reviews Genetics
Volume10
Issue number7
DOIs
StatePublished - Jul 1 2009
Externally publishedYes

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