TY - JOUR
T1 - Making a diagnosis of VWD.
AU - Branchford, Brian R.
AU - Di Paola, Jorge
PY - 2012
Y1 - 2012
N2 - A clear understanding of the molecular basis of VWD can guide the choice and interpretation of appropriate diagnostic tests. This review briefly describes the lifecycle and molecular interactions of VWF and how they lead to the current clinical classification. It also includes a brief discussion of the differential diagnosis and general workup of mucocutaneous bleeding, a review of the various VWD subtypes, and pertinent laboratory assays for each, including genetic tests. Finally, common testing pitfalls and diagnostic dilemmas are covered, including the challenge created by the overlap of borderline low VWF levels and mild bleeding.
AB - A clear understanding of the molecular basis of VWD can guide the choice and interpretation of appropriate diagnostic tests. This review briefly describes the lifecycle and molecular interactions of VWF and how they lead to the current clinical classification. It also includes a brief discussion of the differential diagnosis and general workup of mucocutaneous bleeding, a review of the various VWD subtypes, and pertinent laboratory assays for each, including genetic tests. Finally, common testing pitfalls and diagnostic dilemmas are covered, including the challenge created by the overlap of borderline low VWF levels and mild bleeding.
UR - http://www.scopus.com/inward/record.url?scp=84879397042&partnerID=8YFLogxK
U2 - 10.1182/asheducation.v2012.1.161.3798231
DO - 10.1182/asheducation.v2012.1.161.3798231
M3 - Review article
C2 - 23233576
AN - SCOPUS:84879397042
SN - 1520-4391
VL - 2012
SP - 161
EP - 167
JO - Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program
JF - Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program
ER -