Major non-ABO incompatibility caused by anti-Jka in a patient before allogeneic hematopoietic stem cell transplantation

Miriam Y. Kim, Preeti Chaudhary, Ira A. Shulman, Vinod Pullarkat

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

A 49-year-old white man with blood group AB, D+ was found to have alloanti-Jka and -K when he developed a delayed hemolytic transfusion reaction before allogeneic hematopoietic stem cell transplant (HSCT). Given that his stem cell donor was blood group O, D+, Jk(a+), K-, rituximab was added to his conditioning regimen of fludarabine and melphalan to prevent hemolysis of engrafting Jk(a+) donor red blood cells. The patient proceeded to receive a peripheral blood stem cell transplant from a matched unrelated donor with no adverse events. To our knowledge, this is the first case of successful management of major non-ABO incompatibility caused by anti-Jka in a patient receiving an allogeneic HSCT reported in the literature.

Original languageEnglish
Pages (from-to)11-14
Number of pages4
JournalImmunohematology
Volume29
Issue number1
DOIs
StatePublished - 2013

Keywords

  • Anti-Jk
  • Hematopoietic stem cell transplantation
  • Major incompatibility

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