The ability of an organism to distinguish self from nonself is determined by a cluster of genes located in the major histocompatibility complex. Recent advances in molecular genetics and cellular immunology have begun to elucidate the mechanisms responsible for immune response regulation. In this review article, the genetic organization of the murine and human major histocompatibility complexes and the manner by which their gene products modulate immune responsiveness are discussed.

Original languageEnglish
Pages (from-to)172-181
Number of pages10
JournalJournal of Surgical Research
Issue number2
StatePublished - Aug 1985


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