Major histocompatibility complex regulation of the immune response

David H. Gutmann; John E. Niederhuber

doi:10.1016/0022-4804(85)90175-1

Major histocompatibility complex regulation of the immune response

David H. Gutmann, John E. Niederhuber

Research output: Contribution to journal › Article › peer-review

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Abstract

The ability of an organism to distinguish self from nonself is determined by a cluster of genes located in the major histocompatibility complex. Recent advances in molecular genetics and cellular immunology have begun to elucidate the mechanisms responsible for immune response regulation. In this review article, the genetic organization of the murine and human major histocompatibility complexes and the manner by which their gene products modulate immune responsiveness are discussed.

Original language	English
Pages (from-to)	172-181
Number of pages	10
Journal	Journal of Surgical Research
Volume	39
Issue number	2
DOIs	https://doi.org/10.1016/0022-4804(85)90175-1
State	Published - Aug 1985

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title = "Major histocompatibility complex regulation of the immune response",

abstract = "The ability of an organism to distinguish self from nonself is determined by a cluster of genes located in the major histocompatibility complex. Recent advances in molecular genetics and cellular immunology have begun to elucidate the mechanisms responsible for immune response regulation. In this review article, the genetic organization of the murine and human major histocompatibility complexes and the manner by which their gene products modulate immune responsiveness are discussed.",

author = "Gutmann, {David H.} and Niederhuber, {John E.}",

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AU - Niederhuber, John E.

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AB - The ability of an organism to distinguish self from nonself is determined by a cluster of genes located in the major histocompatibility complex. Recent advances in molecular genetics and cellular immunology have begun to elucidate the mechanisms responsible for immune response regulation. In this review article, the genetic organization of the murine and human major histocompatibility complexes and the manner by which their gene products modulate immune responsiveness are discussed.

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U2 - 10.1016/0022-4804(85)90175-1

DO - 10.1016/0022-4804(85)90175-1

M3 - Article

C2 - 3894799

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SN - 0022-4804

VL - 39

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EP - 181

JO - Journal of Surgical Research

JF - Journal of Surgical Research

IS - 2

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Major histocompatibility complex regulation of the immune response

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