TY - JOUR
T1 - Major dietary patterns and the risk of colorectal cancer in women
AU - Fung, Teresa
AU - Hu, Frank B.
AU - Fuchs, Charles
AU - Giovannucci, Edward
AU - Hunter, David J.
AU - Stampfer, Meir J.
AU - Colditz, Graham A.
AU - Willett, Walter C.
PY - 2003/2/10
Y1 - 2003/2/10
N2 - Background: Several foods and nutrients have been implicated in the development of colon and rectal cancers. In this study, we prospectively assessed the associations between major dietary patterns and the risks of these 2 cancers in women. Methods: Using dietary information collected in 1984, 1986, 1990, and 1994 from 76 402 women aged 38 to 63 years without a history of cancer in 1984, we conducted factor analysis and identified 2 major dietary patterns: "prudent" and "Western." We calculated factor scores for each participant and examined prospectively the associations between dietary patterns and colon and rectal cancer risks. Results: The prudent pattern was characterized by higher intakes of fruits, vegetables, legumes, fish, poultry, and whole grains, while the Western pattern, by higher intakes of red and processed meats, sweets and desserts, french fries, and refined grains. During 12 years of followup, we identified 445 cases of colon cancer and 101 cases of rectal cancer. After adjusting for potential confounders, we observed a relative risk for colon cancer of 1.46 (95% confidence interval, 0.97-2.19) when comparing the highest with the lowest quintiles of the Western pattern (P value for trend across quintiles, .02). The prudent pattern had a nonsignificant inverse association with colon cancer (relative risk for fifth quintile compared with the first, 0.71; 95% confidence interval, 0.50-1.00; P for trend across quintiles, .31). We did not observe any significant association between dietary patterns and rectal cancer. Conclusion: We found a significant positive association between the Western dietary pattern and the risk of colon cancer.
AB - Background: Several foods and nutrients have been implicated in the development of colon and rectal cancers. In this study, we prospectively assessed the associations between major dietary patterns and the risks of these 2 cancers in women. Methods: Using dietary information collected in 1984, 1986, 1990, and 1994 from 76 402 women aged 38 to 63 years without a history of cancer in 1984, we conducted factor analysis and identified 2 major dietary patterns: "prudent" and "Western." We calculated factor scores for each participant and examined prospectively the associations between dietary patterns and colon and rectal cancer risks. Results: The prudent pattern was characterized by higher intakes of fruits, vegetables, legumes, fish, poultry, and whole grains, while the Western pattern, by higher intakes of red and processed meats, sweets and desserts, french fries, and refined grains. During 12 years of followup, we identified 445 cases of colon cancer and 101 cases of rectal cancer. After adjusting for potential confounders, we observed a relative risk for colon cancer of 1.46 (95% confidence interval, 0.97-2.19) when comparing the highest with the lowest quintiles of the Western pattern (P value for trend across quintiles, .02). The prudent pattern had a nonsignificant inverse association with colon cancer (relative risk for fifth quintile compared with the first, 0.71; 95% confidence interval, 0.50-1.00; P for trend across quintiles, .31). We did not observe any significant association between dietary patterns and rectal cancer. Conclusion: We found a significant positive association between the Western dietary pattern and the risk of colon cancer.
UR - http://www.scopus.com/inward/record.url?scp=0037429115&partnerID=8YFLogxK
U2 - 10.1001/archinte.163.3.309
DO - 10.1001/archinte.163.3.309
M3 - Article
C2 - 12578511
AN - SCOPUS:0037429115
SN - 0003-9926
VL - 163
SP - 309
EP - 314
JO - Archives of internal medicine
JF - Archives of internal medicine
IS - 3
ER -