Maintenance rituximab following induction chemoimmunotherapy may prolong progression-free survival in mantle cell lymphoma: A pilot study from the Wisconsin Oncology Network

B. S. Kahl, W. L. Longo, J. C. Eickhoff, J. Zehnder, C. Jones, J. Blank, T. McFarland, W. Bottner, H. Rezazedeh, J. Werndli, H. H. Bailey

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95 Scopus citations

Abstract

Background: There is no standard first line treatment for mantle cell lymphoma. Patients and methods: This was a multicenter phase II pilot study of rituximab and modified hyper-fractionated cyclophosphamide, vincristine doxorubicin, dexamethasone (modified R-hyperCVAD) administered every 28 days for four to six cycles followed by rituximab maintenance therapy consisting of four weekly doses every 6 months for 2 years. Unlike traditional hyperCVAD regimens, no methotrexate or cytarabine was administered. Results: Of 22 patients, the overall response rate was 77% and the complete response rate was 64%. With a median follow-up time of 37 months in surviving patients, the median PFS was 37 months and the median OS was not reached. The achievement of a molecular remission did not correlate with improved outcome. The major toxicity was expected myelosuppression. Two patients died during induction treatment. There were no major adverse effects during maintenance therapy. Conclusion: In a multicenter trial, modified R-hyperCVAD was tolerable and effective induction therapy for untreated MCL. Maintenance rituximab appeared to prolong PFS without increasing toxicity.

Original languageEnglish
Pages (from-to)1418-1423
Number of pages6
JournalAnnals of Oncology
Volume17
Issue number9
DOIs
StatePublished - Sep 2006

Keywords

  • Biologic therapy
  • Chemotherapy
  • Mantle cell lymphoma

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