TY - JOUR
T1 - MaHPIC malaria systems biology data from Plasmodium cynomolgi sporozoite longitudinal infections in macaques
AU - DeBarry, Jeremy D.
AU - Nural, Mustafa V.
AU - Pakala, Suman B.
AU - Nayak, Vishal
AU - Warrenfeltz, Susanne
AU - Humphrey, Jay
AU - Lapp, Stacey A.
AU - Cabrera-Mora, Monica
AU - Brito, Cristiana F.A.
AU - Jiang, Jianlin
AU - Saney, Celia L.
AU - Hankus, Allison
AU - Stealey, Hannah M.
AU - DeBarry, Megan B.
AU - Lackman, Nicolas
AU - Legall, Noah
AU - Lee, Kevin
AU - Tang, Yan
AU - Gupta, Anuj
AU - Trippe, Elizabeth D.
AU - Bridger, Robert R.
AU - Weatherly, Daniel Brent
AU - Peterson, Mariko S.
AU - Jiang, Xuntian
AU - Tran, Vi Linh
AU - Uppal, Karan
AU - Fonseca, Luis L.
AU - Joyner, Chester J.
AU - Karpuzoglu, Ebru
AU - Cordy, Regina J.
AU - Meyer, Esmeralda V.S.
AU - Wells, Lance L.
AU - Ory, Daniel S.
AU - Lee, F. Eun Hyung
AU - Tirouvanziam, Rabindra
AU - Gutiérrez, Juan B.
AU - Ibegbu, Chris
AU - Lamb, Tracey J.
AU - Pohl, Jan
AU - Pruett, Sarah T.
AU - Jones, Dean P.
AU - Styczynski, Mark P.
AU - Voit, Eberhard O.
AU - Moreno, Alberto
AU - Galinski, Mary R.
AU - Kissinger, Jessica C.
N1 - Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - Plasmodium cynomolgi causes zoonotic malarial infections in Southeast Asia and this parasite species is important as a model for Plasmodium vivax and Plasmodium ovale. Each of these species produces hypnozoites in the liver, which can cause relapsing infections in the blood. Here we present methods and data generated from iterative longitudinal systems biology infection experiments designed and performed by the Malaria Host-Pathogen Interaction Center (MaHPIC) to delve deeper into the biology, pathogenesis, and immune responses of P. cynomolgi in the Macaca mulatta host. Infections were initiated by sporozoite inoculation. Blood and bone marrow samples were collected at defined timepoints for biological and computational experiments and integrative analyses revolving around primary illness, relapse illness, and subsequent disease and immune response patterns. Parasitological, clinical, haematological, immune response, and -omic datasets (transcriptomics, proteomics, metabolomics, and lipidomics) including metadata and computational results have been deposited in public repositories. The scope and depth of these datasets are unprecedented in studies of malaria, and they are projected to be a F.A.I.R., reliable data resource for decades.
AB - Plasmodium cynomolgi causes zoonotic malarial infections in Southeast Asia and this parasite species is important as a model for Plasmodium vivax and Plasmodium ovale. Each of these species produces hypnozoites in the liver, which can cause relapsing infections in the blood. Here we present methods and data generated from iterative longitudinal systems biology infection experiments designed and performed by the Malaria Host-Pathogen Interaction Center (MaHPIC) to delve deeper into the biology, pathogenesis, and immune responses of P. cynomolgi in the Macaca mulatta host. Infections were initiated by sporozoite inoculation. Blood and bone marrow samples were collected at defined timepoints for biological and computational experiments and integrative analyses revolving around primary illness, relapse illness, and subsequent disease and immune response patterns. Parasitological, clinical, haematological, immune response, and -omic datasets (transcriptomics, proteomics, metabolomics, and lipidomics) including metadata and computational results have been deposited in public repositories. The scope and depth of these datasets are unprecedented in studies of malaria, and they are projected to be a F.A.I.R., reliable data resource for decades.
UR - http://www.scopus.com/inward/record.url?scp=85142630862&partnerID=8YFLogxK
U2 - 10.1038/s41597-022-01755-y
DO - 10.1038/s41597-022-01755-y
M3 - Article
C2 - 36433985
AN - SCOPUS:85142630862
SN - 2052-4463
VL - 9
JO - Scientific data
JF - Scientific data
IS - 1
M1 - 722
ER -