Magnetic tweezers force spectroscopy

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

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The magnetic tweezers has contributed to a unique set of discoveries about both the fundamental physics of nucleic acids and the mechanisms through which enzymes manipulate these polymers. Since its invention more than 20 years ago, it has been used to study a wide range of topics including the linear and torsional elasticity of DNA and the activities of protein translocases, topoisomerases, polymerases, and helicases. Here, the basic setup of a magnetic tweezers microscope is covered in addition to specific modifications and variations in the technique. Selected examples from the literature are provided throughout in an attempt to survey of the diversity of applications of this technique.

Original languageEnglish
Title of host publicationHandbook of Imaging in Biological Mechanics
PublisherCRC Press
Number of pages9
ISBN (Electronic)9781466588141
ISBN (Print)9781466588134
StatePublished - Jan 1 2014


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