TY - JOUR
T1 - Magnetic resonance molecular imaging with nanoparticles
AU - Lanza, Gregory M.
AU - Winter, Patrick M.
AU - Caruthers, Shelton D.
AU - Morawski, Anne M.
AU - Schmieder, Anne H.
AU - Crowder, Katherine C.
AU - Wickline, Samuel A.
PY - 2004
Y1 - 2004
N2 - Molecular imaging agents are extending the potential of noninvasive medical diagnosis from basic gross anatomic descriptions to complicated phenotypic characterizations based on the recognition of unique cell surface biochemical signatures. Although originally the purview of nuclear medicine, molecular imaging is now a prominent feature of most clinically relevant imaging modalities, in particular magnetic resonance (MR) imaging. MR nanoparticulate agents afford the opportunity not only for targeted diagnostic studies but also for image-monitored site-specific therapeutic delivery, much like the "magic bullet" envisioned by Paul Erhlich 100 years ago. Combining high-resolution MR molecular imaging with drug delivery will facilitate verification and quantification of treatment (ie, rational targeted therapy) and will offer new clinical approaches to many diseases.
AB - Molecular imaging agents are extending the potential of noninvasive medical diagnosis from basic gross anatomic descriptions to complicated phenotypic characterizations based on the recognition of unique cell surface biochemical signatures. Although originally the purview of nuclear medicine, molecular imaging is now a prominent feature of most clinically relevant imaging modalities, in particular magnetic resonance (MR) imaging. MR nanoparticulate agents afford the opportunity not only for targeted diagnostic studies but also for image-monitored site-specific therapeutic delivery, much like the "magic bullet" envisioned by Paul Erhlich 100 years ago. Combining high-resolution MR molecular imaging with drug delivery will facilitate verification and quantification of treatment (ie, rational targeted therapy) and will offer new clinical approaches to many diseases.
UR - http://www.scopus.com/inward/record.url?scp=10944248079&partnerID=8YFLogxK
U2 - 10.1016/j.nuclcard.2004.09.002
DO - 10.1016/j.nuclcard.2004.09.002
M3 - Article
C2 - 15592197
AN - SCOPUS:10944248079
SN - 1071-3581
VL - 11
SP - 733
EP - 743
JO - Journal of Nuclear Cardiology
JF - Journal of Nuclear Cardiology
IS - 6
ER -