TY - GEN
T1 - Magnetic resonance elastography of the mouse vitreous humor in vivo
AU - Clayton, E. H.
AU - Wang, Q.
AU - Song, S. K.
AU - Okamoto, R. J.
AU - Bayly, P. V.
PY - 2012
Y1 - 2012
N2 - Magnetic resonance elastography (MRE) is a novel experimental technique for estimating the dynamic shear modulus of biological tissue in vivo and non-invasively. Propagating acoustic frequency shear waves are launched into biologic tissue via external mechanical actuator and a conventional magnetic resonance imaging (MRI) scanner is used to acquire spatial-temporal measurements of the wave displacement field with micron precision. Local shear modulus estimates are obtained by inverting the equations governing shear wave motion. Changes in tissue pathology may be accompanied by a stark change in tissue elasticity. As a result, MRE has appeal to healthcare practitioners as a non-invasive diagnostic tool. Recently, MRE-based modulus estimates have been obtained in animal liver, brain, and heart [2-7]. Here, for the first time, MRE was used to probe the shear modulus of mouse eye vitreous humor in vivo and non-invasively.
AB - Magnetic resonance elastography (MRE) is a novel experimental technique for estimating the dynamic shear modulus of biological tissue in vivo and non-invasively. Propagating acoustic frequency shear waves are launched into biologic tissue via external mechanical actuator and a conventional magnetic resonance imaging (MRI) scanner is used to acquire spatial-temporal measurements of the wave displacement field with micron precision. Local shear modulus estimates are obtained by inverting the equations governing shear wave motion. Changes in tissue pathology may be accompanied by a stark change in tissue elasticity. As a result, MRE has appeal to healthcare practitioners as a non-invasive diagnostic tool. Recently, MRE-based modulus estimates have been obtained in animal liver, brain, and heart [2-7]. Here, for the first time, MRE was used to probe the shear modulus of mouse eye vitreous humor in vivo and non-invasively.
UR - http://www.scopus.com/inward/record.url?scp=84867214319&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:84867214319
SN - 9781441995285
T3 - Conference Proceedings of the Society for Experimental Mechanics Series
SP - 129
EP - 133
BT - Applications of Imaging Techniques to Mechanics of Materials and Structures - Proceedings of the 2010 Annual Conference on Experimental and Appied Mechanics
T2 - 2010 Annual Conference on Experimental and Applied Mechanics
Y2 - 7 June 2010 through 10 June 2010
ER -