Magnetic resonance elastography of the mouse vitreous humor in vivo

E. H. Clayton, Q. Wang, S. K. Song, R. J. Okamoto, P. V. Bayly

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Magnetic resonance elastography (MRE) is a novel experimental technique for estimating the dynamic shear modulus of biological tissue in vivo and non-invasively. Propagating acoustic frequency shear waves are launched into biologic tissue via external mechanical actuator and a conventional magnetic resonance imaging (MRI) scanner is used to acquire spatial-temporal measurements of the wave displacement field with micron precision. Local shear modulus estimates are obtained by inverting the equations governing shear wave motion. Changes in tissue pathology may be accompanied by a stark change in tissue elasticity. As a result, MRE has appeal to healthcare practitioners as a non-invasive diagnostic tool. Recently, MRE-based modulus estimates have been obtained in animal liver, brain, and heart [2-7]. Here, for the first time, MRE was used to probe the shear modulus of mouse eye vitreous humor in vivo and non-invasively.

Original languageEnglish
Title of host publicationApplications of Imaging Techniques to Mechanics of Materials and Structures - Proceedings of the 2010 Annual Conference on Experimental and Appied Mechanics
Pages129-133
Number of pages5
StatePublished - Oct 12 2012
Event2010 Annual Conference on Experimental and Applied Mechanics - Indianapolis, IN, United States
Duration: Jun 7 2010Jun 10 2010

Publication series

NameConference Proceedings of the Society for Experimental Mechanics Series
Volume4
ISSN (Print)2191-5644
ISSN (Electronic)2191-5652

Conference

Conference2010 Annual Conference on Experimental and Applied Mechanics
Country/TerritoryUnited States
CityIndianapolis, IN
Period06/7/1006/10/10

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