Magnetic resonance and positron emission tomography imaging of the corpus callosum: size, shape and metabolic rate in unipolar depression

Joseph C. Wu, Monte S. Buchsbaum, J. Chad Johnson, Tamara G. Hershey, Edward A. Wagner, Cheuk Tung, Stephen Lottenberg

Research output: Contribution to journalArticle

50 Scopus citations

Abstract

Magnetic resonance imaging (MRI) and positron emission tomography (PET) with fluorodeoxyglucose were used to study the size and shape of the corpus callosum in 20 patients with unipolar depressive disorder and 16 normal controls. An automated algorithm outlined the corpus callosum and divided it into quarters. The anterior and posterior quarters of the corpus callosum were larger in depressed patients than in controls, findings similar to most earlier MRI studies of the corpus callosum in schizophrenics. The patient-normal difference was more marked in females than in males. PET glucose metabolic values were higher in patients with thinner or smaller callosums. The presence of marked sex differences makes future larger studies controlling body size and age important.

Original languageEnglish
Pages (from-to)15-25
Number of pages11
JournalJournal of affective disorders
Volume28
Issue number1
DOIs
StatePublished - May 1993
Externally publishedYes

Keywords

  • Cerebral metabolic rate
  • Corpus callosum
  • Deoxyglucose
  • Genu
  • Splenium

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