Abstract
In this commentary we discuss new findings presented by Shang et al. regarding the role of macrophage-derived glutamine in skeletal muscle repair. Loss-of-function of glutamate dehydrogenase in macrophages led to an upregulation of glutamine synthesis which sustained glutamine levels in muscle tissue and facilitated satellite cell proliferation and differentiation.
Original language | English |
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Article number | e210013 |
Journal | Immunometabolism (United States) |
Volume | 3 |
Issue number | 2 |
DOIs | |
State | Published - Feb 19 2021 |
Keywords
- amino acids
- inflammation
- macrophage metabolism
- muscle repair
- satellite cells