Abstract

In this commentary we discuss new findings presented by Shang et al. regarding the role of macrophage-derived glutamine in skeletal muscle repair. Loss-of-function of glutamate dehydrogenase in macrophages led to an upregulation of glutamine synthesis which sustained glutamine levels in muscle tissue and facilitated satellite cell proliferation and differentiation.

Original languageEnglish
Article numbere210013
JournalImmunometabolism (United States)
Volume3
Issue number2
DOIs
StatePublished - Feb 19 2021

Keywords

  • amino acids
  • inflammation
  • macrophage metabolism
  • muscle repair
  • satellite cells

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