Macrophages as regulators of tumour immunity and immunotherapy

David G. DeNardo, Brian Ruffell

Research output: Contribution to journalReview articlepeer-review

643 Scopus citations

Abstract

Macrophages are critical mediators of tissue homeostasis, with tumours distorting this proclivity to stimulate proliferation, angiogenesis and metastasis. This had led to an interest in targeting macrophages in cancer, and preclinical studies have demonstrated efficacy across therapeutic modalities and tumour types. Much of the observed efficacy can be traced to the suppressive capacity of macrophages, driven by microenvironmental cues such as hypoxia and fibrosis. As a result, tumour macrophages display an ability to suppress T cell recruitment and function as well as to regulate other aspects of tumour immunity. With the increasing impact of cancer immunotherapy, macrophage targeting is now being evaluated in this context. Here, we discuss the results of clinical trials and the future of combinatorial immunotherapy.

Original languageEnglish
Pages (from-to)369-382
Number of pages14
JournalNature Reviews Immunology
Volume19
Issue number6
DOIs
StatePublished - Jun 1 2019

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