TY - JOUR
T1 - Macrophages and dendritic cells in islets of Langerhans in diabetic autoimmunity
T2 - a lesson on cell interactions in a mini-organ
AU - Carrero, Javier A.
AU - Ferris, Stephen T.
AU - Unanue, Emil R.
N1 - Publisher Copyright:
© 2016 Elsevier Ltd
PY - 2016/12/1
Y1 - 2016/12/1
N2 - Islets of Langerhans of all species harbor a small number of resident macrophages. These macrophages are found since birth, do not exchange with blood monocytes, and are maintained by a low level of replication. Under steady state conditions, the islet macrophages are in an activated state. Islet macrophages have an important homeostatic role in islet physiology. At the start of the autoimmune process in the NOD mouse, a small number of CD103+ dendritic cells (DC) are found at about the same time that CD4+ T cells also appear in islets. In the absence of the CD103+ DC in the Batf3 deficient mice, autoimmunity never develops. We discuss the interactions among the two phagocytes and beta cells that result in autoimmune diabetes in NOD mice.
AB - Islets of Langerhans of all species harbor a small number of resident macrophages. These macrophages are found since birth, do not exchange with blood monocytes, and are maintained by a low level of replication. Under steady state conditions, the islet macrophages are in an activated state. Islet macrophages have an important homeostatic role in islet physiology. At the start of the autoimmune process in the NOD mouse, a small number of CD103+ dendritic cells (DC) are found at about the same time that CD4+ T cells also appear in islets. In the absence of the CD103+ DC in the Batf3 deficient mice, autoimmunity never develops. We discuss the interactions among the two phagocytes and beta cells that result in autoimmune diabetes in NOD mice.
UR - http://www.scopus.com/inward/record.url?scp=84992083998&partnerID=8YFLogxK
U2 - 10.1016/j.coi.2016.09.004
DO - 10.1016/j.coi.2016.09.004
M3 - Review article
C2 - 27710840
AN - SCOPUS:84992083998
SN - 0952-7915
VL - 43
SP - 54
EP - 59
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
ER -