TY - JOUR
T1 - Macrophage roles in peripheral nervous system injury and pathology
T2 - Allies in neuromuscular junction recovery
AU - Rios, Rachel
AU - Jablonka-Shariff, Albina
AU - Broberg, Curtis
AU - Snyder-Warwick, Alison K.
N1 - Funding Information:
Supported by the NIH National Institute of Neurological Disorders and Stroke K08NS096232 (to A.K.S.W.) and the NIH National Heart Lung Blood Institute training grant 5 T35 HL 7815-25 (to R.R.).
Publisher Copyright:
© 2021 Elsevier Inc.
PY - 2021/3
Y1 - 2021/3
N2 - Peripheral nerve injuries remain challenging to treat despite extensive research on reparative processes at the injury site. Recent studies have emphasized the importance of immune cells, particularly macrophages, in recovery from nerve injury. Macrophage plasticity enables numerous functions at the injury site. At early time points, macrophages perform inflammatory functions, but at later time points, they adopt pro-regenerative phenotypes to support nerve regeneration. Research has largely been limited, however, to the injury site. The neuromuscular junction (NMJ), the synapse between the nerve terminal and end target muscle, has received comparatively less attention, despite the importance of NMJ reinnervation for motor recovery. Macrophages are present at the NMJ following nerve injury. Moreover, in denervating diseases, such as amyotrophic lateral sclerosis (ALS), macrophages may also play beneficial roles at the NMJ. Evidence of positive macrophages roles at the injury site after peripheral nerve injury and at the NMJ in denervating pathologies suggest that macrophages may promote NMJ reinnervation. In this review, we discuss the intersection of nerve injury and immunity, with a focus on macrophages.
AB - Peripheral nerve injuries remain challenging to treat despite extensive research on reparative processes at the injury site. Recent studies have emphasized the importance of immune cells, particularly macrophages, in recovery from nerve injury. Macrophage plasticity enables numerous functions at the injury site. At early time points, macrophages perform inflammatory functions, but at later time points, they adopt pro-regenerative phenotypes to support nerve regeneration. Research has largely been limited, however, to the injury site. The neuromuscular junction (NMJ), the synapse between the nerve terminal and end target muscle, has received comparatively less attention, despite the importance of NMJ reinnervation for motor recovery. Macrophages are present at the NMJ following nerve injury. Moreover, in denervating diseases, such as amyotrophic lateral sclerosis (ALS), macrophages may also play beneficial roles at the NMJ. Evidence of positive macrophages roles at the injury site after peripheral nerve injury and at the NMJ in denervating pathologies suggest that macrophages may promote NMJ reinnervation. In this review, we discuss the intersection of nerve injury and immunity, with a focus on macrophages.
KW - Glial cells
KW - Macrophage
KW - Nerve injury
KW - Nerve regeneration
KW - Neuromuscular junction
UR - http://www.scopus.com/inward/record.url?scp=85099375621&partnerID=8YFLogxK
U2 - 10.1016/j.mcn.2021.103590
DO - 10.1016/j.mcn.2021.103590
M3 - Review article
C2 - 33422671
AN - SCOPUS:85099375621
SN - 1044-7431
VL - 111
JO - Molecular and Cellular Neuroscience
JF - Molecular and Cellular Neuroscience
M1 - 103590
ER -