@article{d9220e6548d44680882d02fd53b6a4f3,
title = "Macrophage Plasticity and Function in the Eye and Heart",
abstract = "Macrophages are important mediators of inflammation and tissue remodeling. Recent insights into the heterogeneity of macrophage subpopulations have renewed interest in their functional diversity in homeostasis and disease. In addition, their plasticity enables them to perform a variety of functions in response to changing tissue contexts, such as those imposed by aging. These qualities make macrophages particularly intriguing cells given their dichotomous role in protecting against, or accelerating, diseases of the cardiovascular system and the eye, two tissues that are particularly susceptible to the effects of aging. We review novel perspectives on macrophage biology, as informed by recent studies detailing the diversity of macrophage identity and function, as well as mechanisms influencing macrophage behavior that might offer opportunities for new therapeutic strategies.",
keywords = "aging, disease, eye, heart, heterogeneity, macrophage, plasticity",
author = "Zelun Wang and Koenig, {Andrew L.} and Lavine, {Kory J.} and Apte, {Rajendra S.}",
note = "Funding Information: This work was supported by National Institutes of Health (NIH) grants R01 EY019287 06A1 (R.S.A.), R01 HL138466 (K.J.L.), R01 HL139714 (K.J.L.), R21 EY026707 02 (R.S.A.), K08 HL123519 (K.J.L.), Vision Core Grant P30 EY02687, Institutional National Research Service Award 5 T32 EY013360 from the National Eye Institute (Z.W.), 5 T32 HL13463502 Training in Integrative and Systems Biology of Cardiovascular Disease (A.L.K.), Glenn Foundation for Medical Research Award (R.S.A.), Starr Foundation (R.S.A.), Kuzma Family Gift Fund (R.S.A.), Jeffrey Fort Innovation Fund (R.S.A.), Edward N. and Della L. Thome Foundation Award (R.S.A.), the Vitreoretinal Surgery Foundation (ZW), Burroughs Wellcome Fund (1014782) (K.J.L.), Children's Discovery Institute of Washington University and St. Louis Children's Hospital (CHII-2015–462 and CH-II-2017–628) (K.J.L.), the Foundation of Barnes-Jewish Hospital (8038–88) (K.J.L.), and an unrestricted grant from Research to Prevent Blindness, Inc. New York, NY to the Department of Ophthalmology, Washington University School of Medicine, St. Louis, MO. Figures were created with BioRender.com. Funding Information: This work was supported by National Institutes of Health (NIH) grants R01 EY019287 06A1 (R.S.A.), R01 HL138466 (K.J.L.), R01 HL139714 (K.J.L.), R21 EY026707 02 (R.S.A.), K08 HL123519 (K.J.L.), Vision Core Grant P30 EY02687 , Institutional National Research Service Award 5 T32 EY013360 from the National Eye Institute (Z.W.), 5 T32 HL13463502 Training in Integrative and Systems Biology of Cardiovascular Disease (A.L.K.), Glenn Foundation for Medical Research Award (R.S.A.), Starr Foundation (R.S.A.), Kuzma Family Gift Fund (R.S.A.), Jeffrey Fort Innovation Fund (R.S.A.), Edward N. and Della L. Thome Foundation Award (R.S.A.), the Vitreoretinal Surgery Foundation (ZW), Burroughs Wellcome Fund (1014782) (K.J.L.), Children{\textquoteright}s Discovery Institute of Washington University and St. Louis Children{\textquoteright}s Hospital ( CHII-2015–462 and CH-II-2017–628 ) (K.J.L.), the Foundation of Barnes-Jewish Hospital (8038–88) (K.J.L.), and an unrestricted grant from Research to Prevent Blindness , Inc., New York, NY to the Department of Ophthalmology, Washington University School of Medicine, St. Louis, MO. Figures were created with BioRender.com . Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",
year = "2019",
month = sep,
doi = "10.1016/j.it.2019.07.002",
language = "English",
volume = "40",
pages = "825--841",
journal = "Trends in Immunology",
issn = "1471-4906",
number = "9",
}