Macrophage growth factor and its relationship to colony stimulating factor

C. C. Stewart, H. Lin

Research output: Contribution to journalReview article

20 Scopus citations


The results of this study clearly show that MGF exquisitely regulates mononuclear phagocyte proliferation. When MGF is removed from the medium, proliferating macrophages leave the cell cycle and enter a resting phase which is completely reversible when MGF is readded to the medium. These normal cells responding to a single stimulating factor should provide a model system useful in comparing the molecular biologic events involved in the regulation of cell proliferation. Such studies with these normal cells may also lead to a better understanding of events which take place during neoplastic transformation.

Original languageEnglish
Pages (from-to)269-285
Number of pages17
JournalRES Journal of the Reticuloendothelial Society
Issue number4
StatePublished - Dec 1 1978

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