Macrophage growth factor and its relationship to colony stimulating factor

C. C. Stewart, H. Lin

    Research output: Contribution to journalReview articlepeer-review

    22 Scopus citations


    The results of this study clearly show that MGF exquisitely regulates mononuclear phagocyte proliferation. When MGF is removed from the medium, proliferating macrophages leave the cell cycle and enter a resting phase which is completely reversible when MGF is readded to the medium. These normal cells responding to a single stimulating factor should provide a model system useful in comparing the molecular biologic events involved in the regulation of cell proliferation. Such studies with these normal cells may also lead to a better understanding of events which take place during neoplastic transformation.

    Original languageEnglish
    Pages (from-to)269-285
    Number of pages17
    JournalRES Journal of the Reticuloendothelial Society
    Issue number4
    StatePublished - Dec 1 1978


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