The results of this study clearly show that MGF exquisitely regulates mononuclear phagocyte proliferation. When MGF is removed from the medium, proliferating macrophages leave the cell cycle and enter a resting phase which is completely reversible when MGF is readded to the medium. These normal cells responding to a single stimulating factor should provide a model system useful in comparing the molecular biologic events involved in the regulation of cell proliferation. Such studies with these normal cells may also lead to a better understanding of events which take place during neoplastic transformation.
|Number of pages||17|
|Journal||RES Journal of the Reticuloendothelial Society|
|State||Published - Dec 1 1978|