Abstract
The results of this study clearly show that MGF exquisitely regulates mononuclear phagocyte proliferation. When MGF is removed from the medium, proliferating macrophages leave the cell cycle and enter a resting phase which is completely reversible when MGF is readded to the medium. These normal cells responding to a single stimulating factor should provide a model system useful in comparing the molecular biologic events involved in the regulation of cell proliferation. Such studies with these normal cells may also lead to a better understanding of events which take place during neoplastic transformation.
Original language | English |
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Pages (from-to) | 269-285 |
Number of pages | 17 |
Journal | RES Journal of the Reticuloendothelial Society |
Volume | 23 |
Issue number | 4 |
State | Published - Dec 1 1978 |