TY - JOUR
T1 - Macrophage Biology, Classification, and Phenotype in Cardiovascular Disease
T2 - JACC Macrophage in CVD Series (Part 1)
AU - Williams, Jesse W.
AU - Giannarelli, Chiara
AU - Rahman, Adeeb
AU - Randolph, Gwendalyn J.
AU - Kovacic, Jason C.
N1 - Publisher Copyright:
© 2018 American College of Cardiology Foundation
PY - 2018/10/30
Y1 - 2018/10/30
N2 - Macrophages represent one of the most numerous and diverse leukocyte types in the body. Furthermore, they are important regulators and promoters of many cardiovascular disease programs. Their functions range from sensing pathogens to digesting cell debris, modulating inflammation, and producing key cytokines and other regulatory factors throughout the body. Macrophage research has undergone a renaissance in recent years, which has propelled a newfound interest in their heterogeneity as well as a new understanding of ontological differences in their development. In addition, recent technological advances such as single-cell mass-cytometry by time-of-flight have enabled phenotype and functional analyses of individual immune myeloid cells, including macrophages, at unprecedented resolution. In this Part 1 of a 4-part review series covering the macrophage in cardiovascular disease, we focus on the basic principles of macrophage development, heterogeneity, phenotype, tissue-specific differentiation, and functionality as a basis to understand their role in cardiovascular disease.
AB - Macrophages represent one of the most numerous and diverse leukocyte types in the body. Furthermore, they are important regulators and promoters of many cardiovascular disease programs. Their functions range from sensing pathogens to digesting cell debris, modulating inflammation, and producing key cytokines and other regulatory factors throughout the body. Macrophage research has undergone a renaissance in recent years, which has propelled a newfound interest in their heterogeneity as well as a new understanding of ontological differences in their development. In addition, recent technological advances such as single-cell mass-cytometry by time-of-flight have enabled phenotype and functional analyses of individual immune myeloid cells, including macrophages, at unprecedented resolution. In this Part 1 of a 4-part review series covering the macrophage in cardiovascular disease, we focus on the basic principles of macrophage development, heterogeneity, phenotype, tissue-specific differentiation, and functionality as a basis to understand their role in cardiovascular disease.
KW - atherosclerosis
KW - cardiovascular
KW - macrophage
UR - http://www.scopus.com/inward/record.url?scp=85054901549&partnerID=8YFLogxK
U2 - 10.1016/j.jacc.2018.08.2148
DO - 10.1016/j.jacc.2018.08.2148
M3 - Review article
C2 - 30360826
AN - SCOPUS:85054901549
SN - 0735-1097
VL - 72
SP - 2166
EP - 2180
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
IS - 18
ER -