Lysosome impairment as a trigger for inflammation in obesity: The proof is in the fat.

David R. Rawnsley; Abhinav Diwan

doi:10.1016/j.ebiom.2020.102824

Lysosome impairment as a trigger for inflammation in obesity: The proof is in the fat.

Research output: Contribution to journal › Comment/debate

Abstract

Obesity is a global epidemic contributing to the rising prevalence of multiple disorders including metabolic syndrome, diabetes, fatty liver disease, cardiovascular and cerebrovascular disease, Alzheimer's disease and certain cancers.

Original language	English
Article number	102824
Journal	EBioMedicine
Volume	56
DOIs	https://doi.org/10.1016/j.ebiom.2020.102824
State	Published - Jun 2020

Keywords

CD36
Lysosome
Obesity
Pre-adipocytes

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10.1016/j.ebiom.2020.102824

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title = "Lysosome impairment as a trigger for inflammation in obesity: The proof is in the fat.",

abstract = "Obesity is a global epidemic contributing to the rising prevalence of multiple disorders including metabolic syndrome, diabetes, fatty liver disease, cardiovascular and cerebrovascular disease, Alzheimer's disease and certain cancers.",

keywords = "CD36, Lysosome, Obesity, Pre-adipocytes",

author = "Rawnsley, \{David R.\} and Abhinav Diwan",

note = "Funding Information: The authors thank Nada Abumrad, PhD, Washington University School of Medicine for helpful discussion. A.D. was supported by grants from the Department of Veterans Affairs ( I01BX004235 ) and the National Institutes of Health ( HL143431 ). D.R.R. was supported by 5T32-HL07081. The funders had no direct role in writing this commentary. Publisher Copyright: {\textcopyright} 2020",

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doi = "10.1016/j.ebiom.2020.102824",

language = "English",

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T1 - Lysosome impairment as a trigger for inflammation in obesity

T2 - The proof is in the fat.

AU - Rawnsley, David R.

AU - Diwan, Abhinav

N1 - Funding Information: The authors thank Nada Abumrad, PhD, Washington University School of Medicine for helpful discussion. A.D. was supported by grants from the Department of Veterans Affairs ( I01BX004235 ) and the National Institutes of Health ( HL143431 ). D.R.R. was supported by 5T32-HL07081. The funders had no direct role in writing this commentary. Publisher Copyright: © 2020

PY - 2020/6

Y1 - 2020/6

N2 - Obesity is a global epidemic contributing to the rising prevalence of multiple disorders including metabolic syndrome, diabetes, fatty liver disease, cardiovascular and cerebrovascular disease, Alzheimer's disease and certain cancers.

AB - Obesity is a global epidemic contributing to the rising prevalence of multiple disorders including metabolic syndrome, diabetes, fatty liver disease, cardiovascular and cerebrovascular disease, Alzheimer's disease and certain cancers.

KW - CD36

KW - Lysosome

KW - Obesity

KW - Pre-adipocytes

UR - https://www.scopus.com/pages/publications/85087111250

U2 - 10.1016/j.ebiom.2020.102824

DO - 10.1016/j.ebiom.2020.102824

M3 - Comment/debate

C2 - 32540774

AN - SCOPUS:85087111250

SN - 2352-3964

VL - 56

JO - EBioMedicine

JF - EBioMedicine

M1 - 102824

ER -

Lysosome impairment as a trigger for inflammation in obesity: The proof is in the fat.

Abstract

Keywords

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