Lysosome impairment as a trigger for inflammation in obesity: The proof is in the fat.

David R. Rawnsley, Abhinav Diwan

Research output: Contribution to journalComment/debate

Abstract

Obesity is a global epidemic contributing to the rising prevalence of multiple disorders including metabolic syndrome, diabetes, fatty liver disease, cardiovascular and cerebrovascular disease, Alzheimer's disease and certain cancers. A renewed sense of urgency is required as obesity remains an intractable problem, despite a rapidly expanding armamentarium of behavioral, pharmacologic and surgical approaches which fall short of delivering sustained results

Original languageEnglish
Article number102824
JournalEBioMedicine
Volume56
DOIs
StatePublished - Jun 2020

Keywords

  • CD36
  • Lysosome
  • Obesity
  • Pre-adipocytes

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