Lysis of Human Promyelocytic HL-60 Cells by Amphotericin B in Combination with 2-Chloroethyl-l-nitrosoureas: Role of the Carbamoylating Activity of Nitrosoureas

Janina Brajtburg, Svetlana Elberg, Gerald Medoff, Kenneth B. Schechtman

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The combinations of amphotericin B (AmB) with l-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) or 2-cyclohexyl isocyanate, the carbamoylating decomposition product of CCNU, were more potent in lysing HL-60 cells than the combinations of AmB with l,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) or 2-chloroethyl isocyanate, the carbamoylating decomposition product of BCNU. The noncarbamoylating nitrosoureas l-(2-chlorethyl)-3-(2,6-dioxo-3-piperydyl)-l-nitrosourea and 2-[3-(2-chloroethyl)-3-nitrosoureidol-D-glucopyranose did not alter AmB effects on HL-60 cells. These results indicate that the potentiating action of CCNU and BCNU on the lytic effects of AmB is associated with the carbamoylating activity of these nitrosoureas. It is likely that the greater carbamoylating activity of CCNU, compared to BCNU, is responsible for the differences in potency of the two AmB-drug combinations.

Original languageEnglish
Pages (from-to)3274-3278
Number of pages5
JournalCancer research
Volume50
Issue number11
StatePublished - Jun 1 1990

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