Lymphocytes in cancer development: Polarization towards pro-tumor immunity

Brian Ruffell; David G. DeNardo; Nesrine I. Affara; Lisa M. Coussens

doi:10.1016/j.cytogfr.2009.11.002

Lymphocytes in cancer development: Polarization towards pro-tumor immunity

Brian Ruffell, David G. DeNardo, Nesrine I. Affara, Lisa M. Coussens

Research output: Contribution to journal › Article › peer-review

193 Scopus citations

Abstract

The classic view that the role of immune cells in cancer is primarily one of tumor rejection has been supplanted by a more complex view of leukocytes having both pro- and anti-tumor properties. This shift is due to the now well recognized capabilities of several myeloid cell types that foster pro-tumor programming of premalignant tissue, as well as the discovery that subsets of leukocytes also suppress development and effector functions of lymphocytes important for mediating anti-tumor immunity. In this review, we focus on the underappreciated role that T lymphocytes play in promoting tumor development. This includes, in addition to the role of T regulatory cells, a role for natural killer T cells and CD4⁺ T helper cells in suppressing anti-tumor immunity and promoting cancer growth and metastasis.

Original language	English
Pages (from-to)	3-10
Number of pages	8
Journal	Cytokine and Growth Factor Reviews
Volume	21
Issue number	1
DOIs	https://doi.org/10.1016/j.cytogfr.2009.11.002
State	Published - Feb 2010

Keywords

Cancer
Inflammation
Lymphocytes
Tumors

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10.1016/j.cytogfr.2009.11.002

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title = "Lymphocytes in cancer development: Polarization towards pro-tumor immunity",

abstract = "The classic view that the role of immune cells in cancer is primarily one of tumor rejection has been supplanted by a more complex view of leukocytes having both pro- and anti-tumor properties. This shift is due to the now well recognized capabilities of several myeloid cell types that foster pro-tumor programming of premalignant tissue, as well as the discovery that subsets of leukocytes also suppress development and effector functions of lymphocytes important for mediating anti-tumor immunity. In this review, we focus on the underappreciated role that T lymphocytes play in promoting tumor development. This includes, in addition to the role of T regulatory cells, a role for natural killer T cells and CD4+ T helper cells in suppressing anti-tumor immunity and promoting cancer growth and metastasis.",

keywords = "Cancer, Inflammation, Lymphocytes, Tumors",

author = "Brian Ruffell and DeNardo, {David G.} and Affara, {Nesrine I.} and Coussens, {Lisa M.}",

note = "Funding Information: The authors would like to acknowledge all of the scientists who made contributions to the areas of research reviewed here that were not cited due to space constraints. The authors acknowledge support from Postdoctoral Awards from the Department of Defense Breast Cancer Research Program (BR) , the American Cancer Society (DGN), and the A merican Association for Cancer Research (NIA) , as well as grants from the National Institutes of Health , the Dr. Susan Love Research Foundation, and a Department of Defense Era of Hope Scholar Award (LMC). ",

year = "2010",

month = feb,

doi = "10.1016/j.cytogfr.2009.11.002",

language = "English",

volume = "21",

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journal = "Cytokine and Growth Factor Reviews",

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T1 - Lymphocytes in cancer development

T2 - Polarization towards pro-tumor immunity

AU - Ruffell, Brian

AU - DeNardo, David G.

AU - Affara, Nesrine I.

AU - Coussens, Lisa M.

N1 - Funding Information: The authors would like to acknowledge all of the scientists who made contributions to the areas of research reviewed here that were not cited due to space constraints. The authors acknowledge support from Postdoctoral Awards from the Department of Defense Breast Cancer Research Program (BR) , the American Cancer Society (DGN), and the A merican Association for Cancer Research (NIA) , as well as grants from the National Institutes of Health , the Dr. Susan Love Research Foundation, and a Department of Defense Era of Hope Scholar Award (LMC).

PY - 2010/2

Y1 - 2010/2

N2 - The classic view that the role of immune cells in cancer is primarily one of tumor rejection has been supplanted by a more complex view of leukocytes having both pro- and anti-tumor properties. This shift is due to the now well recognized capabilities of several myeloid cell types that foster pro-tumor programming of premalignant tissue, as well as the discovery that subsets of leukocytes also suppress development and effector functions of lymphocytes important for mediating anti-tumor immunity. In this review, we focus on the underappreciated role that T lymphocytes play in promoting tumor development. This includes, in addition to the role of T regulatory cells, a role for natural killer T cells and CD4+ T helper cells in suppressing anti-tumor immunity and promoting cancer growth and metastasis.

AB - The classic view that the role of immune cells in cancer is primarily one of tumor rejection has been supplanted by a more complex view of leukocytes having both pro- and anti-tumor properties. This shift is due to the now well recognized capabilities of several myeloid cell types that foster pro-tumor programming of premalignant tissue, as well as the discovery that subsets of leukocytes also suppress development and effector functions of lymphocytes important for mediating anti-tumor immunity. In this review, we focus on the underappreciated role that T lymphocytes play in promoting tumor development. This includes, in addition to the role of T regulatory cells, a role for natural killer T cells and CD4+ T helper cells in suppressing anti-tumor immunity and promoting cancer growth and metastasis.

KW - Cancer

KW - Inflammation

KW - Lymphocytes

KW - Tumors

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U2 - 10.1016/j.cytogfr.2009.11.002

DO - 10.1016/j.cytogfr.2009.11.002

M3 - Article

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AN - SCOPUS:77549085849

SN - 1359-6101

VL - 21

SP - 3

EP - 10

JO - Cytokine and Growth Factor Reviews

JF - Cytokine and Growth Factor Reviews

IS - 1

ER -

Lymphocytes in cancer development: Polarization towards pro-tumor immunity

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